Elucidating Novel Bacterial Targets and Designing Unusual Antimicrobial Peptides: Two Faces of the Same Proteomic Coin
Octávio L. Franco*
Loyalty Graduate Program in Genomic Sciences and Biotechnology, Center of Analysis, Biochemical and proteomics, Catholic University of Brasilia, Brazil
- *Corresponding Author:
- Octávio L. Franco
Centre for Proteomic and Biochemical Analysis
Graduate Studies in Biotechnology and Genomic Sciences
SGAN 916 North Avenue W5 - Module C - Room 222
PO Box 70790-160 - Brasilia, DF – Brazil
Tel: (61) 3448-7220
Fax: (61) 3347-4797
E-mail: [email protected]
Received date: February 11, 2014; Accepted date: March 18, 2014; Published date: March 21, 2014
Citation: Franco OL (2014) Elucidating Novel Bacterial Targets and Designing Unusual Antimicrobial Peptides: Two Faces of the Same Proteomic Coin. J Proteomics Bioinform S8:001. doi: 10.4172/jpb.S8-001
Copyright: © 2014 Franco OL. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Antibiotics are essential compounds used for the control of bacterial infectious diseases. Resistance to antibiotics has become a worldwide public health problem. Therefore, effective therapy in treating resistant bacteria is essential and, to accomplish this, a comprehensive understanding of mechanisms that trigger drug resistance must be sought. The development of novel pharmacies, here focused on antimicrobial peptides (AMPs), has also been a remarkable challenge. To fill the manifold gaps that remain in clarifying bacterial resistance as well in the discovery of novel peptides with antimicrobial properties, proteomic tools have been pioneeringly used. In this context, this review focuses on novel proteomics techniques, on novel bacterial targets that could be used for drug design and on multiple AMPs found in different organisms. Moreover, the many difficulties and pitfalls in this field are also addressed, to shed some light on the two faces of the same proteomic coin.