Elucidating the Molecular Basis of Multiple Sclerosis and Understanding the Disease Pathophysiology
Mohammed Eiman MA*
Immunology Laboratory, Kuwait Cancer Control Centre, Yacob Behbehani Centre, Kuwait
- *Corresponding Author:
- Eiman MA Mohammeds
Immunology laboratory, Kuwait Cancer Control Centre
Yacob Behbehani Centre
Ministry of Health, Shuwaikh, Kuwait
E-mail: [email protected]
Received Date: August 22, 2016; Accepted Date: October 15, 2016; Published Date: October 24, 2016
Citation: Mohammed Eiman MA (2016) Elucidating the Molecular Basis of Multiple Sclerosis and Understanding the Disease Pathophysiology. Immunome Res 12:125. doi: 10.4172/1745-7580.10000125
Copyright: © 2016 Mohammed Eiman MA, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Multiple sclerosis (MS) is a complex, multifactorial autoimmune disorder of the central nervous system (CNS) that causes inflammation, demyelination and neurodegeneration. The increased prevalence of this disease in Arabian Gulf Countries (AGCs) has captivated the author. The following is a deliberative review of the disease with respect to its molecular basis. Briefly, it considers disease pathophysiology though the molecular composition of the cell; the genome, epigenome and mitochondrial genome; and relates these factors to environmental, etiological factors, including: vitamin D, UVR, EBV infection, smoking and obesity. All in all, this review aims to explain the reasons underlying the increasing prevalence of MS in AGCs.