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Research Article

Emerging Concepts and Designing Effectiveness Research in the Process of Care of Patients Hospitalized with an Uncomplicated Acute Coronary Syndrome

Baris Gencer1,2*, François Girardin3,4,5, Philippe Sigaud1, Philippe Meyer1, Marco Roffi1, Stéphane Noble1 and François Mach1
1Cardiology Division, Department of Medicine, Geneva University Hospital, Switzerland
2Division of Clinical Epidemiology, Geneva University Hospital, Switzerland
3Clinical Psychopharmacology Unit, Service of Clinical Pharmacy and Toxicology, Geneva University Hospital, Switzerland
4Medical Directorate, Geneva University Hospital, Switzerland
5Centre for Health Economics, University of York, York, United Kingdom
Corresponding Author : Baris Gencer, MD
Cardiology Division
Department of Medicine
Geneva University Hospital
Street Gabrielle Perret-Gentil 4
1211 Geneva 14, Switzerland
Tel: 0041 79 553 35 33
Fax: 0041 22 382 50 18
E-mail: [email protected]
Received June 28, 2013; Accepted August 13, 2013; Published Augugst 16, 2013
Citation: Gencer B, Girardin F, Sigaud P, Meyer P, Roffi M, et al. (2013) Emerging Concepts and Designing Effectiveness Research in the Process of Care of Patients Hospitalized with an Uncomplicated Acute Coronary Syndrome. J Clin Trials 3:132. doi:10.4172/2167-0870.1000132
Copyright: © 2013 Gencer B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Clinical researchers are major actors in translating evidence-based medicine into the care of patients. Acute Coronary Syndrome (ACS) is a good example for the implementation of complex intervention in the current context of growing economic pressure. According to the 2012 European Society of Cardiology guidelines, early discharge (approximately 72 hours of hospitalization) is reasonable in selected low-risk patients hospitalized with STEMI (ST-elevation myocardial infarction), if early rehabilitation is arranged. However, early discharge is not widely applied in clinical practice, and the potential barriers to shorten LOS have not been studied for patients hospitalized with an ACS.
Method: We will prospectively enroll 200 patients hospitalized with an ACS at the Geneva University Hospital using a before (100 patients, 2012-2013) and after (100 patients, 2013-2014) prospective cohort design. We will implement a systematic intervention consisting of four steps: (1) identification of low-risk patients treated successfully with percutaneous intervention using the Zwolle index Score; (2) targeting promptly an early discharge date within 72 hours after admission; (3) definition of a standard process of care during the hospital stay and (4) referral to a cardiac rehabilitation program within 10 days.
As primary outcome, we will assess the evolution of LOS using administrative data.
As secondary outcomes, we will analyze the potential barriers to an early discharge, the indicators of quality of care and the cost benefits comparing both periods before and after the implementation of an early discharge strategy. We will also assess the safety with a phone call at 30-day.
Summary: In the area of increase concerns on the long-term sustainability of the current health system,
translational science focusing on clinical effectiveness is more than needed. The systematic application of evidencebased recommendation is a way to improve the efficiency of process of care, as well as the transition from inpatient to outpatient setting.

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