alexa Emerging Roles of ADAP, SKAP55, and SKAP-HOM for Integrin and NF-κB Signaling in T cells
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

Emerging Roles of ADAP, SKAP55, and SKAP-HOM for Integrin and NF-κB Signaling in T cells

Amelie Witte1, Janine Degen1, Kathleen Baumgart1, Natalie Waldt1, Benno Kuropka2, Christian Freund2, Burkhart Schraven1,3 and Stefanie Kliche1*
1Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, D-39120 Magdeburg, Germany
2Institute of Chemistry and Biochemistry – Biochemistry – Freie Universität Berlin, D-14195 Berlin, Germany
3Department of Immune Control, Helmholtz Centre for Infection Research, D-38124 Braunschweig, Germany
Corresponding Author : Stefanie Kliche
Institute of Molecular and Clinical Immunology
Otto-von-Guericke University, Leipzigerstr. 44
D-39120 Magdeburg, Germany
Tel: +493916715855
Fax: +493916715852
E-mail: [email protected]
Received August 02, 2012; Accepted September, 08 2012; Published September 14, 2012
Citation: Witte A, Degen J, Baumgart K, Waldt N, Kuropka B, et al. (2012) Emerging Roles of ADAP, SKAP55, and SKAP-HOM for Integrin and NF-κB Signaling in T cells. J Clin Cell Immunol S12:002. doi:10.4172/2155-9899.S12-002
Copyright: © 2012 Witte A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Adapter proteins are scaffolding proteins that lack enzymatic or transcriptional activity. They play a crucial role in the organization of signalosomes, which are molecular complexes involved in signal transduction. Here, we review some of the recent findings regarding the three cytosolic adapter proteins ADAP, SKAP55, and SKAP-HOM with respect to their role in T-cell adhesion, migration and proliferation.

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