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ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Commentary

Emerging Systemic Therapeutic Approaches for Personalized Medicine in Squamous Cell Carcinoma of the Lung

Grace Kho Dy*
Department of Medicine, Roswell Park Cancer Institute, USA
Corresponding Author : Grace Kho Dy, MD
Department of Medicine
Roswell Park Cancer Institute
Buffalo, NY, USA
E-mail: [email protected]
Received March 01, 2012; Accepted March 21, 2012; Published March 23, 2012
Citation: Dy GK (2012) Emerging Systemic Therapeutic Approaches for Personalized Medicine in Squamous Cell Carcinoma of the Lung. J Cancer Sci Ther S11:003. doi: 10.4172/1948-5956.S11-003
Copyright: © 2012 Dy GK. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

During the past decade, a number of novel agents developed for the treatment of advanced NSCLC had, by coincidence, shown survival benefit predominantly among patients with nonsquamous histology, namely pemetrexed (anti-folate), bevacizumab (VEGF pathway inhibition), erlotinib/gefitinib (EGFR receptor tyrosine kinase inhibitors) and crizotinib (ALK receptor tyrosine kinase inhibitor. This has sparked a heightened interest in discovering key molecular aberrations that may be relevant for the treatment of squamous cell carcinoma (SCC) of the lung, a histologic subtype that represents approximately 25% of lung cancer cases diagnosed globally. This article highlights the most promising recent discoveries and targeted agents in development that may be relevant for the treatment of SCC of the lung.

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