alexa Emotional Experience and the Mood-Congruent Working Memory Effect in First-Onset and Untreated Depressive Disorder Patients
ISSN: 2378-5756

Journal of Psychiatry
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Research Article

Emotional Experience and the Mood-Congruent Working Memory Effect in First-Onset and Untreated Depressive Disorder Patients

Li Mi1-3, Lu Shengfu1-3*, Feng Lei4,5, Fu Bingbing4, Wang Gang4,6, Zhong Ning1-3,7 and Hu Bin8

1Laboratory of Intelligent Science & Technology, The International WIC Institute, Beijing University of Technology, Beijing, China

2Beijing International Collaboration Base on Brain Informatics and Wisdom Services, Beijing, China

3Beijing Key Laboratory of MRI and Brain Informatics, Beijing, China

4Mood Disorders Center & China Clinical Research Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China

5Beijing Key Laboratory for Mental Disorders, Beijing, China

6Center of Depression, Beijing Institute for Brain Disorders, Beijing, China

7The Department of Life Science and Informatics, Maebashi Institute of Technology Maebashi, Japan

8Ubiquitous Awareness and Intelligent Solutions Lab, Lanzhou University, Lanzhou, Chi

Corresponding Author:
Shengfu Lu
Laboratory of Intelligent Science & Technology, The International WIC Institute
Beijing University of Technology, Beijing 100024, China
Tel: +86-10-6739-6667

Received Date: May 16, 2016; Accepted Date: July 14, 2016; Published Date: July 20, 2016

Citation: Mi L, Shengfu L, Lei F, Bingbing F, Gang W, et al. (2016) Emotional Experience and the Mood-Congruent Working Memory Effect in First-Onset and Untreated Depressive Disorder Patients. J Psychiatry 19:79. doi:10.4172/2378- 5756.1000379

Copyright: © 2016 Mi L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Using an improved Sternberg working memory paradigm and affective pictures of different valences, this study investigates the emotional experience capability of 22 first-onset and untreated major depressive disorder patients (MDD) compared with the matching 22 healthy control participants (HC) and whether there is a moodcongruent working memory effect. We employed a general linear model analysis of variance (ANOVA) with two-factor repeated measures analysis on the emotional experience capability (pupil diameter changes) and the working memory performance (accuracy). The results show that the pupil diameter changes of positive emotions are significantly greater in MDD than those in HC (p<0.001), and the pupil diameter changes of negative emotions are not significantly different between two groups (p=0.055), which suggest that MDD have a significantly decrease in the ability to experience pleasure (anhedonia). In addition, the results only present that the working memory performances of negative emotions are significantly greater in MDD than those of positive emotions (p<0.05), which indicates that there is a mood-congruent memory effect. Moreover, in MDD, a positive correlation is found between the pupil diameter changes and working memory performances of positive emotions, however there is no correlation between those of negative emotions. Taken together, these results suggest that MDD have a moodcongruent memory effect and anhedonia, and the mood-congruent memory effect may be due to the decreased memory performances of positive emotions (a decrease in the ability to experience pleasure), but not those of negative emotions increased. This study not only illustrates that the core symptoms of depressive patients may be a mood-congruent memory effect and anhedonia but also enriches the connotation of anhedonia as an endophenotype indicator.


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