alexa Enantiomeric Separation and Determination of Stereospecific Drug Release from Marketed Racemic Amlodipine Besylate Tablets by HPLC
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Research Article

Enantiomeric Separation and Determination of Stereospecific Drug Release from Marketed Racemic Amlodipine Besylate Tablets by HPLC

Jagan Mohan Somagoni1,2, Sunil Reddy1, Someshwar Koorelli1, Sarangapani Manda2 and Madhusudan Rao Yamsani1*

1Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal - 506 009 (A.P.) India

2Department of Medicinal Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal - 506 009 (A.P.) India

*Corresponding Author:
Dr. Y. Madhusudan Rao
Centre for Biopharmaceutics and Pharmacokinetics
University College of Pharmaceutical Sciences
Kakatiya University
Warangal - 506 009. (A.P.), India.
Tel: +91-870-2438844
Fax: +91-870-2570543
E-mail: [email protected]

Received date: June 18, 2011; Accepted date: July 09, 2011; Published date: July 11, 2011

Citation: Somagoni J, Reddy S, Koorelli S, Manda S, Yamsani MR (2011) Enantiomeric Separation and Determination of Stereospecific Drug Release from Marketed Racemic Amlodipine Besylate Tablets by HPLC. Pharm Anal Acta 2:129. doi: 10.4172/2153-2435.1000129

Copyright: © 2011 Somagoni J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The objective of carrying out this research work was to investigate the effect of chirality on the stereospecific dissolution of amlodipine from various marketed racemic amlodipine besylate tablets. Amlodipine is a calcium ion influx inhibitor which is used in the treatment of hypertension and angina.

In this study dissolution of various marketed tablets was performed using USP type II apparatus in 0.1 N HCl at 75 rpm with temperature being maintained at 37±0.5 o C. Chromatographic separation of amlodipine enantiomers was performed using HPLC equipped with UV-Visible detector using Chiral AGP column (100 x 4.6 mm I.D., 5μ particle size). There was no significant difference between the cumulative drug release profiles of S and R enantiomers (p>0.05) in 16 out of 20 marketed racemic amlodipine besylate tablets except for amlong, stamlo-5, amlopin-5 and amcard (p<0.05). Though the stereospecificity in the dissolution was found with the four brands i.e., amlong, stamlo-5, amlopin-5 and amcard, the stereospecificity found with Stamlo-5 was quite opposite to the stereospecificity of amlong, amlopin-5 and amcard because the dissolution of R enantiomer of amlong, amlopin-5 and amcard was significantly more compared to their S enantiomer where as in the case of stamlo-5 the dissolution of S enantiomer was more compared to its R enantiomer.

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