alexa Enantioselective Synthesis of β-amino acids: A Review | OMICS International | Abstract
ISSN: 2161-0444

Medicinal Chemistry
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Review Article

Enantioselective Synthesis of β-amino acids: A Review

Muhammad Ashfaq1*, RukhsanaTabassum1, Muhammad Mahboob Ahmad2, Nagina Ali Hassan1, Hiroyuki Oku3 and Gildardo Rivera4

1Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

2Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, Pakistan

3Department of Chemistry & Chemical Biology, Gunma University Kiryu, Gunma 376-8515, Japan

4Centro de Biotecnología, Genómica, Instituto Politécnico Nacional, 88710, Reynosa, México

*Corresponding Author:
Muhammad Ashfaq
Department of Chemistry
The Islamia University of Bahawalpur
Bahawalpur, Pakistan
Tel: +92 300 6829307 +92 62 9255473
Fax: +92 62 9255563
E-mail: [email protected]

Received date: May 05, 2015; Accepted date: July 15, 2015; Published date: July 27, 2015

Citation: Ashfaq M, Tabassum R, Ahmad MM, Hassan NA, Oku H, et al. (2015) Enantioselective Synthesis of β-amino acids: A Review. Med chem 5:295-309. doi: 10.4172/2161-0444.1000278

Copyright: © 2015 Ashfaq M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The synthesis of enantioselective β-amino acids is being reported in this review on account of their significant properties as proteinogenic, non-proteinogenic role such as neurotransmitter, biosynthesizer and nutritional supplementing materials etc. They are extensively used as chiral starting materials, auxiliariesand catalystsin organic synthesis. According to literature evidences, extensive research has been carried out to develop the methodologies for the synthesis of stereoselective β-amino acids. In this review, we describe recent advances in synthetic routes of enantioselective β-amino acids derivatives with chemical reactions during the last decades and to provide the most suitable route of their synthesis to compete the future challenges.

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