Encapsulation of water insoluble drugs in mesoporous silica nanoparticles using supercritical carbon dioxide
- *Corresponding Author:
- Dennis Douroumis
Medway School of Science
Department of Pharmaceutical Sciences
University of Greenwich
Chatham Maritime, ME4 4TB, Kent, UK
E-mail: [email protected]
Received Date: May 24, 2011; Accepted Date: July 09, 2011; Published Date: July 12, 2011
Citation: Patil A, Chirmade UN, Slipper I, Lamprou DA, Urquhart A, Douroumis D (2011) Encapsulation of Water Insoluble Drugs in Mesoporous Silica Nanoparticles using Supercritical Carbon Dioxide. J Nanomedic Nanotechnol 2:111. doi:10.4172/2157-7439.1000111
Copyright: © 2011 Patil A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Mesoporous silica nanoparticles MCM – 41 were synthesized with two dimensional hexagonal p6mm symmetry, high specific surface area(~ 980m2/g) narrow pore size and an average particle size of 186 nm. The produced nanoparticles were used to encapsulate carbamazepine through a supercritical carbon dioxide process combined with various organic solvents. Supercritical processing was found to provide increased drug encapsulation. The loaded MCM - 41 nanoparticles were analyzed using X–ray diffraction and differential scanning calorimetry (DSC) to investigate the crystalline state of the encapsulated carbamazepine and it was found to be dependent on the nature of the organic solvent. Carbamazepine showed increased dissolution rates under sink conditions. Viability studies of Caco – 2 cells demonstrated negligible cytotoxicity for the MCM–41 nanoparticles.