Encouraging Effects of Ethacrynic Acid Derivatives Possessing a Privileged ÃŽÂ±, ÃŽÂ²-Unsaturated Carbonyl Structure Scaffold
Received Date: Jul 08, 2018 / Accepted Date: Jul 17, 2018 / Published Date: Jul 23, 2018
α, β-unsaturated carbonyl unit has remarkable utility in the development of biologically active and therapeutically relevant compounds in medicinal chemistry. In recent years, a number of Ethacrynic acid (EA) derivatives containing α, β-unsaturated carbonyl group were reported, which displayed versatile biological activities, such as antitumor activity, antimalarial effects, antiviral activity and reducing intraocular pressure. In this review, we summed up a number of derivatives regarding Ethacrynic acid as the lead and α, β-unsaturated carbonyl moiety as the functional group, researching on structure-activity relationship and evaluating their various biological activities in recent years. By summarizing the structure-activity relationships of these derivatives, we aimed to demonstrate α, β-unsaturated carbonyl group is a privileged scaffold in these structures and we should pay more attention to α, β-unsaturated carbonyl group to the development of more effectively bioactive new compounds.'
Keywords: α, β-Unsaturated carbonyl; Ethacrynic acid; Derivatives; Biological activities
Citation: Dong J, Yang D, Zhao G (2018) Encouraging Effects of Ethacrynic Acid Derivatives Possessing a Privileged α, β-Unsaturated Carbonyl Structure Scaffold. Med Chem (Los Angeles) 8:185-191. Doi: 10.4172/2161-0444.1000511
Copyright: © 2018 Dong J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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