alexa Encouraging Effects of Ethacrynic Acid Derivatives Possessing a Privileged and#195;and#381;and#194;and#177;, and#195;and#381;and#194;and#178;-Unsaturated Carbonyl Structure Scaffold| Abstract
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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  • Research Article   
  • Med chem (Los Angeles) 2018, Vol 8(7): 185
  • DOI: 10.4172/2161-0444.1000511

Encouraging Effects of Ethacrynic Acid Derivatives Possessing a Privileged α, β-Unsaturated Carbonyl Structure Scaffold

Junze Dong, Dezhi Yang and Guisen Zhao*
Institute of Medicinal Chemistry, Key Laboratory of Chemical Biological (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250000, China
*Corresponding Author : Guisen Zhao, Institute of Medicinal Chemistry, Key Laboratory of Chemical Biological (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan 250012, China, Tel: +8653188382009, Email: [email protected]

Received Date: Jul 08, 2018 / Accepted Date: Jul 17, 2018 / Published Date: Jul 23, 2018

Abstract

α, β-unsaturated carbonyl unit has remarkable utility in the development of biologically active and therapeutically relevant compounds in medicinal chemistry. In recent years, a number of Ethacrynic acid (EA) derivatives containing α, β-unsaturated carbonyl group were reported, which displayed versatile biological activities, such as antitumor activity, antimalarial effects, antiviral activity and reducing intraocular pressure. In this review, we summed up a number of derivatives regarding Ethacrynic acid as the lead and α, β-unsaturated carbonyl moiety as the functional group, researching on structure-activity relationship and evaluating their various biological activities in recent years. By summarizing the structure-activity relationships of these derivatives, we aimed to demonstrate α, β-unsaturated carbonyl group is a privileged scaffold in these structures and we should pay more attention to α, β-unsaturated carbonyl group to the development of more effectively bioactive new compounds.'

Keywords: α, β-Unsaturated carbonyl; Ethacrynic acid; Derivatives; Biological activities

Citation: Dong J, Yang D, Zhao G (2018) Encouraging Effects of Ethacrynic Acid Derivatives Possessing a Privileged α, β-Unsaturated Carbonyl Structure Scaffold. Med Chem (Los Angeles) 8:185-191. Doi: 10.4172/2161-0444.1000511

Copyright: © 2018 Dong J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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