alexa Endocrine and Immunological Alterations under Early Nasal Obstruction in Rats Wistar
ISSN: 2167-0897

Journal of Neonatal Biology
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Research Article

Endocrine and Immunological Alterations under Early Nasal Obstruction in Rats Wistar

Asma Dorbani*, Abdelmadjid Bairi, Mohamed Laid Ouakid and Abdelkrim Tahraoui
Applied Neuroendocrinology Laboratory, Department of Biology, Faculty of Science, University Badji Mokhtar BP 12 23000, Annaba, Algeria
Corresponding Author : Asma Dorbani
Department of Biology, Faculty of Science
University Badji Mokhtar BP 12 23000
Annaba, Algeria
Tel: +2130388721
E-mail: [email protected]
Received: September 09, 2015; Accepted: September 24, 2015; Published: September 30, 2015
Citation: Dorbani A, Bairi A, Ouakid ML, Tahraoui A (2015) Endocrine and Immunological Alterations under Early Nasal Obstruction in Rats Wistar. J Neonatal Biol 4:199.doi:10.4172/2167-0897.1000199
Copyright: © 2015 Dorbani A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

For most animals smell is the primal sense. One they rely on to identify food, predators and mates. Indeed, for many organisms, odours arc their most efficient means of communicating with others and interpreting their surroundings. Innate behaviour in response to smell is essential to these organisms' survival and most likely result s from nonconscious perception of odours. This article is part of a research program dealing with the consequences of bilateral nasal obstruction (NO) during the postnatal development of mammals. Its aim was to test if the absence of nasal respiration and the related transition to chronic oral breathing could perturb the development of the individual. Therefore, a NO was induced in 8-day old rats (D8) and its effects were investigated 24 h after the treatment (D9), at the end of the obstruction period (D15) and six days after the reopening of the nostrils (D21). The results showed that NO affect some hormonal functions, these modifications were pronounced at D9, D15 and D21. Lastly, NO was associated with an atrophy of the brain at D15, it was maintained until D21. In rats, nasal obstruction can thus be considered like a multifactorial stressful situation. Its effects lasted until adulthood.

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