Endorphins on Cancer: A Novel Therapeutic Approach
Department of Oral Medicine and Oral Oncology, Krishna Devaraya College of Dental Sciences and Hospital, Bangalore-562157, Karnataka, India
- *Corresponding Author:
- Shrihari TG
Department of Oral Medicine and Oral Oncology
Krishna Devaraya College of Dental Sciences and Hospital
Bangalore-562157, Karnataka, India
E-mail: [email protected]
Received date: May 13, 2017; Accepted date: July 19, 2017; Published date: July 24, 2017
Citation: Shrihari TG (2017) Endorphins on Cancer: A Novel Therapeutic Approach. J Carcinog Mutagen 8:298. doi: 10.4172/2157-2518.1000298
Copyright: © 2017 Shrihari TG. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Endorphins are natural neuropeptides secreted by anterior pituitary gland through hypothalamus in response to stress full conditions such as physical exercise, yoga and meditation. Stress is also a one of the predisposing factor for cancer by activating inflammatory mediators such as IL-1 and TNF-α, involved in tumor progression. It has stress buster activity by reducing cortisol, analgesic activity by inhibiting substance P, euphoric activity by releasing dopamine and immune-stimulatory activity by activating NK cells, macrophages. It can be used for natural antitumor activity by activating NK cells, macrophage innate immune cells, and has anti-inflammatory activity by inducing IL-12, IL-8 cytokines. It has got it’s receptors on the immune cells, binding of endogenous opioids such as beta endorphin to the receptors on the immune cells, activates immune cells. This article briefs about the role of Beta endorphin on cancers and its anticancer activities.