Endothelium as A Part of Septic Multiple Organ Dysfunction Syndrome (Mods)- Is Endocan an Answer?
|Department of Anesthesiology and Intensive Therapy, Medical University Wroclaw, Poland|
|Corresponding Author :||MaÅgorzata Lipinska-Gediga
IDIBAPS, Department of Anesthesiology
and Intensive Therapy
Medical University Wroclaw, Poland
E-mail: [email protected]
|Received December 15, 2014, Accepted : February 26, 2015, Published February 28, 2015|
|Citation: Lipinska-Gediga M (2015) Endothelium as A Part of Septic Multiple Organ Dysfunction Syndrome (Mods)-Is Endocan an Answer?. J Clin Cell Immunol 6:304. doi: 10.4172/2155-9899.1000304|
|Copyright: © 2015 Lipinska-Gediga M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Sepsis is complex syndrome with endothelial barrier integrity compromise, contributing to end-organ dysfunction. Some findings have established that markers of septic endothelial activation are associated with extent of sepsis severity, organ dysfunction and mortality. Endocan is a novel endothelium derived soluble dermatan sulfate proteoglycan and endocan’s increased serum levels founded in patients with sepsis were of prognostic value.