alexa Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents | OMICS International | Abstract
ISSN: 2329-9495

Angiology: Open Access
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Review Article

Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents

Ilia Fishbein1,2*, Michael Chorny1,2, Richard F Adamo1, Scott P Forbes1, Ricardo A Corrales1, Ivan S Alferiev1,2 and Robert J Levy1,2

1Dept of Pediatrics, Division of Cardiology, The Children’s Hospital of Philadelphia, USA

2The University of Pennsylvania, USA

*Corresponding Author:
Ilia Fishbein
Department of Pediatrics
Division of Cardiology
The Children’s Hospital of Philadelphia, USA
Tel: (215) 590-8740
Fax: (215) 590-5454
E-mail: [email protected]

Received Date: June 27, 2013; Accepted Date: July 25, 2013; Published Date: July 27, 2013

Citation: Fishbein I, Chorny M, Adamo RF, Forbes SP, Corrales RA, et al. (2013) Endovascular Gene Delivery from a Stent Platform: Gene- Eluting Stents. Angiol 1:109. doi:10.4172/2329-9495.1000109

Copyright: © 2013 Fishbein I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A synergistic impact of research in the fields of post-angioplasty restenosis, drug-eluting stents and vascular gene therapy over the past 15 years has shaped the concept of gene-eluting stents. Gene-eluting stents hold promise of overcoming some biological and technical problems inherent to drug-eluting stent technology. As the field of gene-eluting stents matures it becomes evident that all three main design modules of a gene-eluting stent: a therapeutic transgene, a vector and a delivery system are equally important for accomplishing sustained inhibition of neointimal formation in arteries treated with gene delivery stents. This review summarizes prior work on stent-based gene delivery and discusses the main optimization strategies required to move the field of gene-eluting stents to clinical translation.

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