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ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
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Review Article

Engineering of Nanoscale Contrast Agents for Optical Coherence Tomography

Andrew Y Gordon1 and Ashwath Jayagopal1,2*

1 Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, USA

2 Vanderbilt Eye Institute, Vanderbilt University Medical Center, USA

*Corresponding Author:
Ashwath Jayagopal, Ph.D
Department of Molecular Physiology and Biophysics
Vanderbilt University Medical Center- 8010, Nashville
TN 37232, USA
Tel: 615-343-7851
E-mail: [email protected]

Received Date: December 30, 2013; Accepted Date: January 28, 2014; Published Date: January 30, 2014

Citation: Gordon AV, Jayagopal A (2014) Engineering of Nanoscale Contrast Agents for Optical Coherence Tomography. J Nanomed Nanotechol S5:004. doi:10.4172/2157-7439.S5-004

Copyright: © 2014 Lopez Gordon AV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Optical coherence tomography has emerged as valuable imaging modalityin ophthalmology and other fields by enabling high-resolution three-dimensional imaging of tissue. In this paper, we review recent progress in the field of contrast-enhanced optical coherence tomography (OCT). We discuss exogenous and endogenous sources of OCT contrast, focusing on their use with standard OCT systems as well as emerging OCT-based imaging modalities. We include advances in the processing of OCT data that generate improved tissue contrast, including spectroscopic OCT (SOCT), as well as work utilizing secondary light sources and/or detection mechanisms to create and detect enhanced contrast, including photothermal OCT (PTOCT) and photoacoustic OCT (PAOCT). Finally, we conclude with a discussion of the translational potential of these developments as well as barriers to their clinical use.

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