Enhanced Bioavailability and Anticancer Activity of Vitamin Analogs
Kakullamarri PR* and Rao KLN
Research and Development, Ascent Pharmaceuticals, Central Islip, NY, USA
- *Corresponding Author:
- Kakullamarri PR
Research and Development, Ascent Pharmaceuticals
Central Islip, NY, USA
E-mail: [email protected]
Received date: April 24, 2017; Accepted date: June 01, 2017; Published date: June 12, 2017
Citation: Kakullamarri PR, Rao KLN (2017) Enhanced Bioavailability and Anticancer Activity of Vitamin Analogs. J Bioequiv Availab 9:439-441. doi: 10.4172/jbb.1000340
Copyright: © 2017 Kakullamarri PR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
There is increased evidence to show that dietary supplementation of vitamins contributes to cancer prevention and also therapy. This paper explains the anticancer activity of few vitamins and the necessity of preparing their analogs to enhance their bioavailability. While the vitamin supplementation is needed in various health disorders, over supplementation of the same may not be effective due to failure to reach over maximal concentrations in the body. Vitamin mediated anticancer activities include cell cycle progression inhibition, targeting cell survival, inducing autophagy or apoptosis, inhibiting hypoxia, eradication of oxygen free radicals and immune modulation. As the in vitro data seems sufficient to support vitamin biological effects, advanced research is needed to support their in vivo activity and long-term treatment.