alexa Enhancement of Transdermal Delivery of Indomethacin and
ISSN: 2161-1025

Translational Medicine
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Research Article

Enhancement of Transdermal Delivery of Indomethacin and Tamoxifen by Far-Infrared Ray-Emitting Ceramic Material (BIOCERAMIC): A Pilot Study

Shoei Loong Lin1, Wing Pong Chan2, Cheuk-Sing Choy3 and Ting-Kai Leung2,4,5*

1Department of Surgery, Taipei Hospital, Ministry of health and Welfare, Taiwan, Republic of China

2Department of Diagnostic Radiology, Taipei Municipal Wanfang Hospital & Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taiwan, Taiwan, Republic of China

3Department of Emergency and intensive care, Taipei Hospital, Ministry of health and Welfare, Taiwan, Taiwan, Republic of China

4Department of Physics, College of Science and Engineering, Fu Jen Catholic University, Hsinchuang, Taiwan, Taiwan, Republic of China

5Department of Radiology, Taipei Hospital, Ministry of health and Welfare, Taiwan, Taiwan, Republic of China

*Corresponding Author:
Ting-Kai Leung
Department of Diagnostic Radiology
Taipei Medical University, Taipei Hospital
Ministry of Health and Welfare, NO.127
Su Yuan Road, Hsin Chuang District, New Taipei City
242-13, Taiwan, Taiwan, Republic of China
Tel: 886-2-22765566
Fax: (886) 2-23570900035
E-mail: [email protected]

Received Date: August 17, 2013; Accepted Date: September 23, 2013; Published Date: September 25, 2013

Citation: Lin SL, ChanW P, Choy CS, Leung TK (2013) Enhancement of Transdermal Delivery of Indomethacin and Tamoxifen by Far-Infrared Ray- Emitting Ceramic Material (BIOCERAMIC): A Pilot Study. Transl Med 3:115. doi:10.4172/2161-1025.1000115

Copyright: © 2013 La H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

BIOCERAMIC have been found to modulate various biological effects. Our earlier published research on various cell lines demonstrated that BIOCERAMIC promoted microcirculation, upregulated calcium-dependent nitric oxide and calmodulin, and exerted an antioxidant effect by increasing hydrogen peroxide scavenging ability. The development of pain relief systems requires most possible minimum doses and methods for effective local control of pain, so as to protect liver and renal function. There is also clinical necessary to develop targeted delivery of estrogen inhibitor in the breast using a local drug release system, to protect the breast from the increased cancer risk associated with the use of estrogen therapy. We compared the viscosity of BIOCERAMIC irradiated water and control water, and found that BIOCERAMIC might weaken the hydrogen bonds. Such breaks are caused by the loss of hydrogen bond covalence resulting from electron rearrangement. The purposes of this study were thus to investigated a transdermal drug delivery model using Franz cell apparatus for Indomethacin and Tamoxifen. The results showed that BIOCERAMIC enhanced the diffusion and permeability of the drugs. Therefore, we suggest that BIOCERAMIC might enhance the penetration performed by hydrogen bond weakening due to physical induction, and may facilitate local drug delivery in transdermal systems.

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