alexa Enhancing the Activity of Peroxisome Proliferator- Acti
ISSN: 2329-6836

Natural Products Chemistry & Research
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Research Article

Enhancing the Activity of Peroxisome Proliferator- Activated Receptors (PPAR) Activity through Natural Ligand Binding in Diabetes: Substantial Computational Approach

Lakshmi Huttada1, MB Hiremath1* and Niketan Laner D’Souza2
1PG Department of Studies in Biotechnology and Microbiology, Karnataka University, Dharwad-580 003, Karnataka, India
2Sacred Heart Pre-University College, Shimoga-577 201, Karnataka, India
*Corresponding Author : MB Hiremath
PG Department of Studies in Biotechnology and Microbiology
Karnataka University, Dharwad-580 003, Karnataka, India
E-mail: [email protected]
Received: February 24, 2016; Accepted: March 07, 2016; Published: March 15, 2016
Citation: Huttada L, Hiremath MB, D’Souza NL (2016) Enhancing the Activity of Peroxisome Proliferator- Activated Receptor’s (PPAR) Activity through Natural Ligand Binding in Diabetes: Substantial Computational Approach. Nat Prod Chem Res 4:213. doi:10.4172/2329-6836.1000213
Copyright: © 2016 Huttada L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Traditional medicines have been potential in regulating blood glucose control, leading to herbal treatment to manage diabetes from long time. Diabetes is proving to be a major problem throughout the world in the recent years. In spite of synthetic medications available in the market, to reduce the ill effects of diabetes and its secondary complications, herbal formulations are preferred due to less side effects and low cost. Objective: The present study attempts in studying antidiabetic property of an unexploited plant, Exacum pedunculatum, belonging to Gentianaceae family, from the Western Ghats of India. Methodology: The dried plant material was subjected to extraction for isolating compounds which was purified to obtain biguanide compound and screened in silico to study the antidiabetic nature of the compound. Result: Promising phytochemicals are present in the extract of the plant. Exacum pedunculatum which was further studied in silico for the drug activity. The experiment showed that the bioactive compound isolated from the selected plant showed higher activity than the drug molecule (Metformin) available in the market. Conclusion: As diabetes is a multifactorial disease leading to several complications, and demands a multiple therapeutic approach; medicinal plants are being looked up once again for the treatment of diabetes. There is a need for conducting clinical research in herbal drugs, developing simple bioassays for biological standardization, pharmacological and toxicological evaluation, and developing various animal models for toxicity and safety evaluation. It is also important to establish mechanism of action of the active components from these plant extracts.


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