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Eosinophilic Esophagitis and Ige-Mediated Allergy in Children: Specific Ige by Component-Based-Allergen Microarray | OMICS International | Abstract
ISSN: 2155-6121

Journal of Allergy & Therapy
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Research Article

Eosinophilic Esophagitis and Ige-Mediated Allergy in Children: Specific Ige by Component-Based-Allergen Microarray

Francesca Rea1*, Leila Emma D’Urbano2, Rosa Luciano2, Marta Muraca3, Luigi Dall’Oglio1, Giovanni Cavagni4 and Paola De Angelis1

1Digestive Surgery and Endoscopy Unit, Bambino Gesù Children’s Hospital- IRCCS, Rome, Italy

2Pediatric Laboratory Medicine, Bambino Gesù Children’s Hospital- IRCCS, Rome, Italy

3Pediatric Immunology University “La Sapienza”, School of Medicine, Rome

4Pediatric Medicine, Bambino Gesù Children’s Hospital- IRCCS, Rome and European Diagnostic Center DRP, Parma, Italy

*Corresponding Author:
Francesca Rea
Digestive Surgery and Endoscopy Unit
Bambino Gesù Children’s Hospital
IRCCS Piazza Sant’Onofrio 4, 00165, Rome, Italy
Tel: 390668592841
Fax: 390668592949
E-mail: [email protected]

Received date: May 12, 2013; Accepted date: June 18, 2014; Published date: June 25, 2014

Citation:Rea F, D’Urbano LE, Luciano R, Muraca M, Dall’Oglio L, et al. (2014) Eosinophilic Esophagitis and Ige-Mediated Allergy in Children: Specific Ige by Component-Based-Allergen Microarray. J Allergy Ther 5:180. doi: 10.4172/2155-6121.1000180

Copyright: ©2014 Rea F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Atopy is prevalent in eosinophilic esophagitis (EoE) but the relative role of airborn and food allergens in the etiopathogenesis is still incompletely understood; allergic immediate and delayed reactions are involved.
Objective: We characterized the sIgE profile by a component-based allergen microarray with highly purified allergens in EoE in comparison with traditional sIgE assay and we evaluated a possible correlation between clinical features and sIgE results.
Methods: In 30 consecutive patients diagnosed with EoE, three diagnostic tests were performed: skin prick test (SPT), ImmunoCAP®sIgE and an allergen component microarray chip called ImmunoCAP® ISAC. The ISAC chips cover 103 recombinant or purified allergen molecules including food, airborn and cross-reactive allergens.
Results: Out of the 30 patients, 15, 16 and 17 of the patients were sensitized as assess with SPT, ISAC and ImmunoCAP® respectively. Thirteen of the patients were multi-sensitized. The three diagnostic methods were in good agreement for all patients; the ISAC method provided new information in 8 patients, not revealed by the traditional tests, either by detection of panallergens or unsuspected triggering allergens.
Conclusions: sIgE detection by the ISAC microarray revealed that airborne allergens and panallergens are more frequently involved than food allergens in our population. The ISAC data were in agreement with both traditional tests and doctor’s diagnosis/open challenge and revealed new information that can improve understanding of the EoE pathogenesis and management.

Key message: immune-solid phase allergen chip (ISAC) gives new information about cross reactive molecules and identification of panallergens, which are not possible to obtain from traditional test.


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