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ISSN: 2167-1052

Advances in Pharmacoepidemiology and Drug Safety
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Research Article

Epidemiological Study of AGT Gene Polymorphism among Chinese Subjects with Primary Hypertension

Ning Zhang*, Lili Yang, Huadong Cui and Wenyi Fu
Department of Internal Medicine, ShengJing Hospital, China Medical University, Sanhao street36, Heping district, Shenyang, P.R. China
*Corresponding Author : Ning Zhang, Prof.
Dept. of Internal Medicine
Shengjing Hospital of China Medical University
Tel: 0086-24-96615-27102
Fax: 0086-24- 23513451
E-mail: [email protected]
Received March 12, 2012; Accepted May 12, 2012; Published May 15, 2012
Citation: Zhang N, Yang L, Cui H, Fu W (2012) Epidemiological Study of AGT Gene Polymorphism among Chinese Subjects with Primary Hypertension. Adv Pharmacoepidem Drug Safety 1:110. doi:10.4172/2167-1052.1000110
Copyright: © 2012 Zhang N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Polymorphisms in the promoter region of the angiotensinogen (AGT) gene may affect AGT transcription and thus blood pressure. We determined the frequency of the AGT A-20C polymorphism in Chinese patients with primary hypertension. Using a molecular epidemiology approach, we also determined the relationship between primary hypertension and environmental-AGT A-20C polymorphism interactions.
Methods: 912 subjects diagnosed with primary hypertension were analyzed from Shenyang Chinese Populations and their samples were genotyped using A-20C polymorphism within angiotensinogen (AGT) gene by Restriction Fragment Length Polymorphism methods (PCR-RFLP)
Results:
PCR and restriction fragment length polymorphism techniques were used to determine the distribution frequency of AGT A-20C alleles. Frequencies of 84.7% and 15.3% were observed for the A and C alleles, respectively. The polymorphism was in Hardy-Weinberg equilibrium according to a χ2 test (χ2=0.58, P>0.05). Linear regression of AGT genotype and blood pressure revealed that systolic blood pressure was significantly higher for AC and CC genotypes compared to the wild-type AA genotype in females (P<0.05).
Conclusion: This is the first report on the frequency of AGT A-20C polymorphism in a Chinese population. Compared to the AA genotype, the effects of genotypes AC and CC on blood pressure were mainly manifest as significantly higher systolic blood pressure in females.

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