alexa Epidemiology and Neurodevelopmental Correlates of Cobalamin Deficiency in Hospitalized North Indian Infants | OMICS International| Abstract
ISSN: 2472-100X

Journal of Pediatric Neurology and Medicine
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
  • Research Article   
  • J Pediatr Neurol Med 2016, Vol 1(1): 1
  • DOI: 10.4172/2472-100x.1000103

Epidemiology and Neurodevelopmental Correlates of Cobalamin Deficiency in Hospitalized North Indian Infants

Neha Agarwal1, Chandrakanta1, S Koonwar1, AA Mahdi2 and Rashmi Kumar1*
1Departments of Pediatrics, King George’s Medical University, Lucknow, India
2Departments of Biochemistry, King George’s Medical University, Lucknow, India
*Corresponding Author : Rashmi Kumar, Department of Pediatrics, King George’s Medical College, Lucknow 226024, India, Tel: 9415408777, Email: [email protected]

Received Date: Nov 25, 2015 / Accepted Date: Feb 01, 2016 / Published Date: Feb 08, 2016

Abstract

Vitamin B12 deficiency has been associated with neurodevelopmental disorders in infants. Role of maternal and infant diet and other epidemiological features have not been reported from India.

Objective: To compute the prevalence of vitamin B12 deficiency in hospitalized children 2 months to 2 years of age and compare demographic, clinical, dietary and developmental status between those found deficient and sufficient.

Methods: The first 3 children aged 2 months to 2 years hospitalized to the Pediatric Medicine wards of King George’s Medical University Hospital, Lucknow on a predecided weekday were enrolled for study and subjected to a proforma driven work up. Those with history of vitamin supplements were excluded. Vitamin B12 and folate levels were measured by chemiluminiscence method. Vitamin B12 cut off value below 200 pg/ml and folic acid cut off value of <3 ng/ml were considered deficient. Neurodevelopmental status was assessed by Vineland Social Maturity Scale. Demographic data, dietary history of mother and child, anthropometry, clinical features and neurodevelopmental status were compared between the 2 groups.

Results: A total of 91 children [mean age 9.64+/- 4.42 months; 57.1% male] were enrolled, of which 17 [18.7%; 95% CI 11.3-28.2] were vitamin B12 deficient. No child was folic acid deficient. Vitamin B12 deficient children were significantly more likely to belong to lower socioeconomic status, be exclusively breast fed infants of vegetarian mothers with higher mean corpuscular volume and mean corpuscular hemoglobin concentration but lower mean platelet count. They also had higher odds of having a developmental quotient [DQ]<70 [OR=7.8; 95% CI 2.4-24.8; p=0.000] and significantly lower mean DQ [p=0.018].

Conclusion: Clear association of vitamin B12 deficiency with maternal and infant diet and impaired neurodevelopmental status was found which has important implications for millions of children in this country.

Keywords: VitaminB12 deficiency; Cobalamin; Epidemiology; Neurodevelopmental status; Folate deficiency; Maternal diet

Citation: Agarwa N, Chandrakanta, Koonwar S, Mahdi AA, Kumar R (2016) Epidemiology and Neurodevelopmental Correlates of Cobalamin Deficiency in Hospitalized North Indian Infants. J Pediatr Neurol Med 1: 103. Doi: 10.4172/2472-100x.1000103

Copyright: ©2016 Agarwal N, et al., This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Article Usage
  • Total views: 9226
  • [From(publication date): 2-2016 - Jul 19, 2019]
  • Breakdown by view type
  • HTML page views: 9087
  • PDF downloads: 139
Leave Your Message 24x7
Top