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ISSN: 2472-100X

Journal of Pediatric Neurology and Medicine
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  • Research Article   
  • J Pediatr Neurol Med 2016, Vol 1(1): 1
  • DOI: 10.4172/2472-100x.1000103

Epidemiology and Neurodevelopmental Correlates of Cobalamin Deficiency in Hospitalized North Indian Infants

Neha Agarwal1, Chandrakanta1, S Koonwar1, AA Mahdi2 and Rashmi Kumar1*
1Departments of Pediatrics, King George’s Medical University, Lucknow, India
2Departments of Biochemistry, King George’s Medical University, Lucknow, India
*Corresponding Author : Rashmi Kumar, Department of Pediatrics, King George’s Medical College, Lucknow 226024, India, Tel: 9415408777, Email: [email protected]

Received Date: Nov 25, 2015 / Accepted Date: Feb 01, 2016 / Published Date: Feb 08, 2016


Vitamin B12 deficiency has been associated with neurodevelopmental disorders in infants. Role of maternal and infant diet and other epidemiological features have not been reported from India.

Objective: To compute the prevalence of vitamin B12 deficiency in hospitalized children 2 months to 2 years of age and compare demographic, clinical, dietary and developmental status between those found deficient and sufficient.

Methods: The first 3 children aged 2 months to 2 years hospitalized to the Pediatric Medicine wards of King George’s Medical University Hospital, Lucknow on a predecided weekday were enrolled for study and subjected to a proforma driven work up. Those with history of vitamin supplements were excluded. Vitamin B12 and folate levels were measured by chemiluminiscence method. Vitamin B12 cut off value below 200 pg/ml and folic acid cut off value of <3 ng/ml were considered deficient. Neurodevelopmental status was assessed by Vineland Social Maturity Scale. Demographic data, dietary history of mother and child, anthropometry, clinical features and neurodevelopmental status were compared between the 2 groups.

Results: A total of 91 children [mean age 9.64+/- 4.42 months; 57.1% male] were enrolled, of which 17 [18.7%; 95% CI 11.3-28.2] were vitamin B12 deficient. No child was folic acid deficient. Vitamin B12 deficient children were significantly more likely to belong to lower socioeconomic status, be exclusively breast fed infants of vegetarian mothers with higher mean corpuscular volume and mean corpuscular hemoglobin concentration but lower mean platelet count. They also had higher odds of having a developmental quotient [DQ]<70 [OR=7.8; 95% CI 2.4-24.8; p=0.000] and significantly lower mean DQ [p=0.018].

Conclusion: Clear association of vitamin B12 deficiency with maternal and infant diet and impaired neurodevelopmental status was found which has important implications for millions of children in this country.

Keywords: VitaminB12 deficiency; Cobalamin; Epidemiology; Neurodevelopmental status; Folate deficiency; Maternal diet

Citation: Agarwa N, Chandrakanta, Koonwar S, Mahdi AA, Kumar R (2016) Epidemiology and Neurodevelopmental Correlates of Cobalamin Deficiency in Hospitalized North Indian Infants. J Pediatr Neurol Med 1: 103. Doi: 10.4172/2472-100x.1000103

Copyright: ©2016 Agarwal N, et al., This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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