alexa Epidermal Growth Factor (EGF) and Platelet-Derived Growth Factor (PDGF) as Tissue Healing Agents: Clarifying Concerns about their Possible Role in Malignant Transformation and Tumor Progression
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
Open Access

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Review Article

Epidermal Growth Factor (EGF) and Platelet-Derived Growth Factor (PDGF) as Tissue Healing Agents: Clarifying Concerns about their Possible Role in Malignant Transformation and Tumor Progression

Jorge Berlanga-Acosta1*, Jorge Gavilondo-Cowley2, Diana García del Barco-Herrera1, Jorge Martín-Machado3 and Gerardo Guillen-Nieto3

1Tissue Repair and Cyto-Protection Research Group, Biomedical Research Direction. Center for Genetic Engineering and Biotechnology, PO Box 6162, Cuabanacan, Playa 10600. Havana City, Cuba

2Cancer Research Group, Biomedical Research Direction. Center for Genetic Engineering and Biotechnology, PO Box 6162, Cuabanacan, Playa 10600, Havana City, Cuba

3Vaccine Division, Biomedical Research Direction. Center for Genetic Engineering and Biotechnology, PO Box 6162, Cuabanacan, Playa 10600, Havana City, Cuba

*Corresponding Author:
Jorge Berlanga-Acosta, PhD
Tissue Repair and Cyto- Protection Research Group
Biomedical Research Direction
Center for Genetic Engineering and Biotechnology
PO Box 6162, Cuabanacan
Playa 10600, Havana City, Cuba
Tel: (53-7) 2716221
Fax: (53-7) 2714764
E-mail: [email protected] cigb.edu.cu

Received date: Janurary 03, 2011; Accepted date: February 22, 2011; Published date: February 25, 2011

Citation: Berlanga-Acosta J, Gavilondo-Cowley J, del Barco-Herrera DG, Martín- Machado J, Guillen-Nieto G (2011) Epidermal Growth Factor (EGF) and Platelet- Derived Growth Factor (PDGF) as Tissue Healing Agents: Clarifying Concerns about their Possible Role in Malignant Transformation and Tumor Progression. J Carcinogene Mutagene 2:115. doi: 10.4172/2157-2518.1000115

Copyright: © 2011 Berlanga-Acosta J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

EGF and PDGF, reminiscent of the early hopes of solution for problem wounds have attained a niche by healing diabetic ulcers. Although they belong to unrelated families, multiple biological features are shared. Mounting evidences reviewed here; document however, divergent and opposing roles for EGF and PDGF in both tissue repair and tumorigenesis. Wounds: As EGF receptor is not expressed by inflammatory cells, its ligand does not quantitatively or qualitatively modifies the course of inflammation. In contrast, PDGFB recruits and perpetuates inflammation. These infiltrated inflammatory cells turns and additional local source of growth factors. EGF enhances matrix synthesis via gene expression, while PDGF increases wound fibroblasts and myofibroblasts population density and exhibits far more chemotactic and angiogenic effect. Epithelialization is distinctly stimulated by EGF. Oncogenesis: EGF is not an oncogene-derived product and does not render perpetual or irreversible transformation in vitro or in vivo. Its promoting effect is not uniformly reproduced and seems to depend upon the animals genetic background, targeted tissue biology, and/or the chemical carcinogen-induced mutations. A variety EGF receptor mutated forms may confer cell’s self-sufficiency for no need of exogenousgrowth factors supply. PDGFB is an oncogen product, establishes growth-perpetuating autocrine loops and confers self-sufficiency to glial tumorigenesis. Its role as a co-carcinogen as in tumor stroma and neoangiogenesis appears far more defined. Understanding the cellular and molecular imprinting of EGF and PDGF would allow for the judicious medical balance in terms of risk-benefit for the patient.

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