alexa Epigenetic Re-Programming during Mammalian Preimplantat
ISSN: 2375-4508

Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biology
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Review Article

Epigenetic Re-Programming during Mammalian Preimplantation Embryogenesis and PGC Development

Fei Teng1,2 and Qi Zhou1*
1State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
2University of Chinese Academy of Sciences, Beijing 100049, China
*Corresponding Author : Qi Zhou
1 Beichen West Road
Chaoyang District
Beijing 100101, PR China
Tel: +86-10-64807312
Fax: 86-10-64807299
E-mail: [email protected]
Received September 05, 2013; Accepted November 04, 2013; Published November 06, 2013
Citation: Teng Fei, Zhou Fei (2013) Epigenetic Re-Programming during Mammalian Preimplantation Embryogenesis and Pgc Development. J Fertil In Vitro IVF Worldw Reprod Med Genet Stem Cell Biol 1:114. doi: jfiv.1000114
Copyright: © 2013 Teng Fei, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Epigenetic programming and reprogramming, by means of DNA methylation and histone modifications etc., control the mammalian development to a large extent. They are also artificially altered for cell fate conversion and regeneration. Though epigenetic modifications change with slow dynamics during somatic cell lineage differentiation, they undergo a genome-wide dramatic change with extensive DNA de-methylation and histone modification during two specific time windows, the early embryogenesis and the Primordial Germ Cell (PGC) development stage. Here we reviewed these global epigenetic reprogramming occurred during normal development, mainly focusing on DNA methylation, histone modification and X-chromosome inactivation. Epigenetic reprogramming participates in many key biological processes such as genomic imprinting, X-chromosome inactivation, gene expression regulation and tumorigenesis and genome stability. Understanding the mechanisms of epigenetic reprogramming during the early embryogenesis and PGC formation would facilitate our knowledge of the developmental process and disease progress.


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