alexa Epigenetics and Hematopoietic Stem or Progenitor Cells
ISSN: 2161-0436

Human Genetics & Embryology
Open Access

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Review Article

Epigenetics and Hematopoietic Stem or Progenitor Cells

Yang Wang, Benjamin T. Moore, Xianhao Peng and Peng Xiao*
Osteoporosis Research Center, Creighton University Medical Center Omaha, NE 68131, USA
Corresponding Author : Peng Xiao, Ph.D
Osteoporosis Research Center
School of Medicine, Creighton University
601 N. 30th St. Suite 6775, Omaha
NE 68131, USA
Tel: 402-280-4283
Fax: 402-280-4284
E-mail: [email protected]
Received January 02, 2012; Accepted March 02, 2012; Published March 06, 2012
Citation: Wang Y, Moore BT, Peng X, Xiao P (2012) Epigenetics and Hematopoietic Stem or Progenitor Cells. Human Genet Embryol S2:004. doi: 10.4172/2161-0436.S2-004
Copyright: © 2012 Wang Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The maintenance and differentiation of hematopoietic stem/progenitor cells (HSPCs) is a critical process of hematopoiesis that includes the formation of lymphoid lineage and myeloid lineage. Epigenetic regulation is mainly composed of DNA methylation, histone modifications, non-coding microRNA (miRNA) regulation and chromatin remodeling, which are essential for the maintenance and differentiation of hematopoietic stem/progenitor cells (HSPCs). This review details the epigenetic studies of four major epigenetic mechanisms in normal and aberrant HSPCs, as well as hematopoiesis.

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