alexa Epithelial Malignancies Arising in Ovarian Mature Cystic Teratoma: A Series, of 26 Cases
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

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Research Article

Epithelial Malignancies Arising in Ovarian Mature Cystic Teratoma: A Series, of 26 Cases

Ud Din N1*, Minhas K1, Arshad S2 and Kayani N1

1Assistant Professor, Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan

2Resident and Instructor, Department of Histopathology, Aga Khan University Hospital, Karachi, Pakistan

*Corresponding Author:
Ud Din N
Assistant Professor
Department of Pathology and Laboratory Medicine
Aga Khan University Hospital
Karachi, Pakistan
Tel: +922134930051
E-mail: [email protected]

Received Date: October 15, 2015; Accepted Date: January 28, 2016; Published Date: January 30, 2016

Citation: Ud Din N, Minhas K, Arshad S, Kayani N (2016) Epithelial Malignancies Arising in Ovarian Mature Cystic Teratoma: A Series of 26 Cases. J Cytol Histol S5:001. doi:10.4172/2157-7099.S5-001

Copyright: © 2016 Ud Din N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: To report a series of epithelial malignancies arising within ovarian teratomas along with clinical followup. Some previously unreported combinations of malignant component with MCT are also being reported.
Material and Methods: Clinico-pathological details and clinical follow up of twenty six cases reported during January 2000 to March 2014 in the Section of Histopathology, of a tertiary care hospital of Pakistan are included.
Results: Total 1418 cases of MCTs were reported, 26 (1.8%) of them showed epithelial malignancies. The mean age at presentation was 42.5 years (range; 15-70 years). Commonest clinical presentation was with abdominal pain and mass. All the patients underwent surgery as first line treatment. Malignant transformation in form of Squamous cell carcinoma was seen in 20 cases. In one case, in addition to squamous cell carcinoma, atypical proliferative serous tumor and high grade sarcomatous component was also present. Adenosquamous carcinoma, Poorly differentiated carcinoma, Endometrioid adenocarcinoma and Adenocarcinoma with mucinous differentiation represented malignant components in additional 4 cases respectively. Cases demonstrating endometrioid features and atypical proliferative serous tumor represent collision tumors. Two of the cases had papillary carcinoma (follicular variant) of thyroid arising within monodermal teratoma (struma ovarii). Clinical follow up was available in 13 cases and it is noted that patients with squamous cell carcinoma had a worse outcome. Conclusions: Malignancy occurring in a MCT is an extremely rare occurrence. It is very challenging to diagnose this malignant transformation clinically.


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