Epithelial-Myoepithelial Carcinoma of Parotid Gland: A Cytological Challenge with Histological Correlation
Iván Fernández-Vega*, Nelson Fuentes-Martínez, Guillermo E Mendoza, Jorge Santos-Juanes and Florentino Fresno-Forcelledo
Pathology Department of Central University Hospital of Asturias, Oviedo, Spain
- *Corresponding Author:
- Iván Fernández-Vega
Central University Hospital of Asturias
33006, Oviedo, Spain
E-mail: [email protected]
Received Date: December 19, 2012; Accepted Date: December 28, 2012; Published Date: December 31, 2012
Citation: Fernández-Vega I, Fuentes-Martínez N, Mendoza GE, Santos-Juanes J, Fresno-Forcelledo F (2012) Epithelial-Myoepithelial Carcinoma of Parotid Gland: A Cytological Challenge with Histological Correlation. J Cytol Histol 3:156. doi:10.4172/2157-7099.1000156
Copyright: © 2012 Fernández-Vega I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Epithelial-Myoepithelial Carcinoma (EMC) is a rare type of malignant tumor of salivary gland accounting for less than 1.5% of all salivary neoplasms. Differential diagnosis of this tumor is complicated, especially by cytological examinations. Case: We present the case of an 86-year-old female who presented clinically with a bulky lesion behind her right ear. Fine needle aspiration cytology with immunocytochemistry has been performed and the patient was diagnosed with a biphasic neoplasm, epithelial-myoepithelial, highly suggestive of EMC. She underwent a wide surgical excision and diagnostic was confirmed by histological examinations, which showed a tumor composed of ducts with double cell lining surrounded by a basement membrane in a sclerotic stroma. Immunohistochemistry was carried on to highlight the biphasic cell pattern. The patient is free of disease after 20 months of surgical procedure. Conclusion: Although there isn’t any antibody that confirms the diagnosis of EMC, due to the difficulty to make a correct diagnostic of this lesion by cytology, we have highly recommended the use of immunocytochemistry assay as an important tool to confirm the double-cell pattern, which in together with a clinical course may help in the diagnostic of EMC. Cytology and histology correlation are rarely reported.