alexa Epithelial-to-Mesenchymal Transition as a Potential Target for Antineoplastic Therapies | OMICS International | Abstract
ISSN: 2577-0535

Journal of Cancer Clinical Trials
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Epithelial-to-Mesenchymal Transition as a Potential Target for Antineoplastic Therapies

Sushma R Rao1 and Aparna Jayachandran2-6*

1Cell Cycle Unit, Children’s Medical Research Institute, The University of Sydney, 214 Hawkesbury Road, Westmead, New South Wales, Australia

2The University of Queensland School of Medicine and the Gallipoli Medical Research Foundation, Greenslopes Private Hospital, Brisbane, Queensland, Australia

3Ludwig Institute for Cancer Research, Melbourne-Austin Branch, Heidelberg, Victoria, Australia

4Olivia Newton-John Cancer Research Institute, Olivia Newton-John Cancer and Wellness Centre, Heidelberg, Victoria, Australia

5Department of Medicine, University of Melbourne, Victoria, Australia

6School of Cancer Medicine, La Trobe University, Victoria, Australia

*Corresponding Author:
Aparna Jayachandran
Liver Cancer Unit, Gallipoli Medical Research Institute
School of Medicine, The University of Queensland
Lower Lobby Level, Administration Building
Greenslopes Private Hospital
Newdegate Street, Greenslopes QLD 4120, Australia
Tel: +61(7) 33460695
E-mail: [email protected]

Received Date: November 3, 2015 Accepted Date: November 5, 2015 Published Date: November 9, 2015

Citation: Rao SR, Jayachandran A (2015) Epithelial-to-Mesenchymal Transition as a Potential Target for Antineoplastic Therapies. J Cancer Clin Trials 1:e103. doi: 10.4172/jcct.1000e103

Copyright: © 2015 Rao SR and Jayachandran A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Epithelial-to-mesenchymal transition (EMT) is a multi-step reprograming process resulting in a phenotype switch from an epithelial to a mesenchymal state. This phenotype switching of cells, long been studied for its role in development, is now emerging as a crucial process that endows tumor cells with migratory and invasive properties, enriches stem cell-like attributes, enhances drug resistance, prevents apoptosis and contribute to immunosuppression. A comprehensive understanding of EMT cellular program will enable identification and development of potential EMT-targeted antitumor therapeutic strategies. This Editorial briefly describes recent evidence of EMT as a driver of malignancy and evaluates various strategies to target EMT in cancer.


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