Epstein-Barr Virus-Associated Myoid Tumors in Human Immunodeficiency Virus-Infected Patients
- Corresponding Author:
- PK Ramdial
Department of Anatomical Pathology
Level 3, Laboratory Building, Inkosi Albert Luthuli Central Hospital
800 Vusi Mzimela Road, Mayville, 4058
KwaZulu-Natal, South Africa
Tel: +27 (0)31 2402693
Fax: +27(0)31 2402610
E-mail: [email protected]
Received date: July 30, 2016; Accepted date: August 30, 2016; Published date:September 06, 2016
Citation: Khaba MC, Ramdial PK, Pillay B, Steyn AJ, Nargan K (2016) Epstein-Barr Virus-Associated Myoid Tumors in Human Immunodeficiency Virus-Infected Patients. J AIDS Clin Res 7:616. doi:10.4172/2155-6113.1000616
Copyright: © 2016 Khaba MC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Although Epstein Barr Virus (EBV)-associated myoid tumors (EBV-MTs) are a well-recognized entity, commonly associated with immunocompromise and immunosuppression, including Human Immunodeficiency Virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), they are reported uncommonly. An expanding spectrum of EBV-MTs has emerged in the last decade, associated with an increasing range of organ involvement. EBV-MTs are associated with diagnostic pitfalls, incomplete etiopathogenetic understanding and treatment challenges. This review revisits EBV-MTs in the HIV and AIDS setting. The characteristics of EBV, their etiopathogenetic role in neoplasia, in general and in HIV-associated EBV-MTs in particular, are discussed. Historical, demographic and diagnostic clinicopathological features of EBV-MTs are detailed, classification and diagnostic challenges are emphasized, treatment options and dilemmas are presented briefly and outcome-associated factors are described. While attention is drawn to current demographic, classification, etiopathogenetic and management uncertainties and hiatuses, potential future approaches to address these shortcomings are also alluded to.