alexa Epstein-Barr Virus-Associated Myoid Tumors in Human Immunodeficiency Virus-Infected Patients | OMICS International
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

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Review Article

Epstein-Barr Virus-Associated Myoid Tumors in Human Immunodeficiency Virus-Infected Patients

Khaba MC1, Ramdial PK1*, Pillay B2, Steyn AJ3,4 and Nargan K3

1Department of Anatomical Pathology, National Health Laboratory Service & School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, KwaZulu-Natal, South Africa

2Department of Vascular/Endovascular Surgery, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, KwaZulu-Natal, South Africa

3KwaZulu-Natal Research Institute for Tuberculosis and HIV, KwaZulu-Natal, South Africa

4Department of Microbiology and Centers for AIDS Research and Free Radical Biology, University of Alabama at Birmingham, Alabama, USA

Corresponding Author:
PK Ramdial
Department of Anatomical Pathology
Level 3, Laboratory Building, Inkosi Albert Luthuli Central Hospital
800 Vusi Mzimela Road, Mayville, 4058
KwaZulu-Natal, South Africa
Tel: +27 (0)31 2402693
Fax: +27(0)31 2402610
E-mail: [email protected]

Received date: July 30, 2016; Accepted date: August 30, 2016; Published date:September 06, 2016

Citation: Khaba MC, Ramdial PK, Pillay B, Steyn AJ, Nargan K (2016) Epstein-Barr Virus-Associated Myoid Tumors in Human Immunodeficiency Virus-Infected Patients. J AIDS Clin Res 7:616. doi:10.4172/2155-6113.1000616

Copyright: © 2016 Khaba MC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Although Epstein Barr Virus (EBV)-associated myoid tumors (EBV-MTs) are a well-recognized entity, commonly associated with immunocompromise and immunosuppression, including Human Immunodeficiency Virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), they are reported uncommonly. An expanding spectrum of EBV-MTs has emerged in the last decade, associated with an increasing range of organ involvement. EBV-MTs are associated with diagnostic pitfalls, incomplete etiopathogenetic understanding and treatment challenges. This review revisits EBV-MTs in the HIV and AIDS setting. The characteristics of EBV, their etiopathogenetic role in neoplasia, in general and in HIV-associated EBV-MTs in particular, are discussed. Historical, demographic and diagnostic clinicopathological features of EBV-MTs are detailed, classification and diagnostic challenges are emphasized, treatment options and dilemmas are presented briefly and outcome-associated factors are described. While attention is drawn to current demographic, classification, etiopathogenetic and management uncertainties and hiatuses, potential future approaches to address these shortcomings are also alluded to.

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