alexa Escitalopram for Delusion in an Oldest Old Patient with Alzheimer's Disease
ISSN: 2168-975X

Brain Disorders & Therapy
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Case Report

Escitalopram for Delusion in an Oldest Old Patient with Alzheimer's Disease

Sachiko Yokoyama1, Mari Aoki1, Kazunari Azuma1, Koichi Jimbo1, Kimiko Konishi1, Masaki Okada2, Misa Hosoi1 and Koji Hori1,2*
1Department of Psychiatry, Showa University Northern Yokohama Hospital, Kanagawa, Japan
2Department of Psychiatry, Hitachiumegaoka Hospital, Ibaraki, Japan
Corresponding Author : Koji Hori
Department of Psychiatry
Showa University Northern Yokohama Hospital 35-1 Chigasakichuo
Tsuzukiku, Yokohama, Kanagawa 224-8503, Japan
Tel: +81-45-949-7000
Fax: +81-45-949-7927
E-mail: [email protected]
Received Septembet 18, 2013; Accepted October 23, 2013; Published October 25, 2013
Citation: Yokoyama S,Aoki M, Azuma K, Jimbo K, Konishi K, et al. (2013) Escitalopram for Delusion in an Oldest Old Patient with Alzheimer’s Disease. Brain Disord Ther 2:108. doi:10.4172/2168-975X.1000108
Copyright: © 2013 Yokoyama S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Objective: To present a case of Alzheimer’s disease (AD) associated with delusions that were satisfactorily treated with escitalopram. Background: In Japan, there are currently no licensed medicines for the management of the behavioral and psychological symptoms of dementia (BPSD) in AD patients. Patient and Results: We present the case of an 88-year-old woman with AD who developed delusions that were successfully treated with escitalopram. We previously reported that anxiety in elderly AD patients was associated with delusions and hallucinations and was caused by disturbance of the serotonergic system. Therefore, we considered that enhancement of the serotonergic system may be useful for ameliorating delusion in the present AD patient. Escitalopram inhibits the reuptake of serotonin and experts allosteric potentiating actions on serotonin reuptake inhibitors, moreover, it has evidence of efficacy for treating affective symptoms in the old patients. Therefore, this agent may be useful for ameliorating serotonin deficiency and delusion in the oldest old AD patients. Conclusions: Escitalopram may be useful for the management of psychotic symptoms in relatively older patients with AD.

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