alexa Estimation of Irbesartan in Bulk and Dosage Forms by New Simple UV Spectrophotometry Using Hydrotropic Technique | OMICS International | Abstract
ISSN : 2153-2435

Pharmaceutica Analytica Acta
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Research Article

Estimation of Irbesartan in Bulk and Dosage Forms by New Simple UV Spectrophotometry Using Hydrotropic Technique

Srinath Nissankararao* Anil Kumar A, Rama Devi Bhimavarapu and Krishna Prasanna V

Sri Siddhartha Pharmacy College, Nuzvid, Andhra Pradesh, India

*Corresponding Author:
Srinath Nissankararao
Sri Siddhartha Pharmacy College
Nuzvid, Andhra Pradesh, India
Tel: +91–9440449011
E-mail: [email protected]

Received Date: July 03, 2013; Accepted Date: August 22, 2013; Published Date: August 28, 2013

Citation: Nissankararao S, Anil Kumar A, Bhimavarapu RD, Krishna Prasanna V (2013) Estimation of Irbesartan in Bulk and Dosage Forms by New Simple UV Spectrophotometry Using Hydrotropic Technique. Pharm Anal Acta 4:265. doi: 2153-2435.1000265

Copyright: © 2013 Nissankararao S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Irbesartan, chemically, a non peptide tetrazole derivative, has anti hypertensive property. It is an angiotensin II antagonist that selectively blocks the binding of an angiotensin II to the angiotensin I receptor. In present work, a selective, specific, sensitive and economical hydrotropic agent assisted spectroscopic method using 1M sodium bicarbonate and 2M urea (50:50% v/v), as hydrotropic agent; to increase the solubility of poorly water-soluble Irbesartan, has been developed for the estimation of Irbesartan in Bulk and its pharmaceutical dosage forms. An absorption maximum was found to be at 246.4 nm where sodium bicarbonate, urea and other excipients did not show any absorbance above 228 nm and thus no interference in the estimation. Irbesartan was obeyed Beer’s law in the concentration range from 10-35 μg / ml. Proposed method was validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values with correlation coefficient of 0.9998. The percentage recovery of Irbesartan ranged from 99.4-101.3% in pharmaceutical dosage form. Results of the analysis for accuracy, precision, LOD, LOQ and were found to be satisfactory. The proposed method is simple, rapid and suitable for the routine quality control analysis.

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