alexa Estrogen and Pelvic Organ Prolapse
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Research Article

Estrogen and Pelvic Organ Prolapse

Ling Zhou1,2, Anna Junjie Shangguan2, Stacy Ann Kujawa2, Katarzyna Bochenska3, Lanmei Zhang1, Serdar E. Bulun2 and Hong Zhao2*

1Department of Obstetrics and Gynecology, Hospital of the People’s Liberation Army, Beijing, China

2Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, USA

3Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University,Chicago, USA

*Corresponding Author:
Hong Zhao
Division of Reproductive Science in Medicine
Department of Obstetrics and Gynecology
Feinberg School of Medicine at Northwestern University
303 E. Superior Street, Suite 4-121
Chicago, Illinois 60611, USA
Tel: 3125030780
Fax: 3125030095
E-mail: [email protected]

Received date: May 06, 2016; Accepted date: June 12, 2016; Published date: June 17, 2016

Citation: Zhou L, Shangguan AJ, Kujawa SA, Bochenska K, Zhang L, et al. (2016) Estrogen and Pelvic Organ Prolapse. J Mol Genet Med 10:221. doi:10.4172/1747-0862.1000221

Copyright: © 2016 Zhou Ling, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Pelvic organ prolapse (POP) is a multifactorial disease with a complex and largely unknown etiology and pathophysiology. Hypoestrogenemia may be one of the risk factors associated with POP. Recent studies suggest a potential role of estrogen and its receptors in the pathogenesis of POP. Here, we summarize current research regarding the relationship between estrogen and POP to establish a theoretical foundation for using estrogen in POP treatment. Estrogen plays an important role in collagen and elastin metabolism of connective tissues through down-regulating matrix metalloproteinases and increasing cystatin C expression. However, previous studies have shown contradictory data regarding estrogen receptor expression in patients with POP compared to non-POP controls. At this time, there is no conclusive evidence suggesting a causal role of estrogen in POP. Further welldesigned studies are necessary to illuminate both the molecular mechanisms of estrogen function and the role of estrogen in POP.


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