alexa Estrogen and Transdiagnostics: A Systematic Review
ISSN: 2167-1044

Journal of Depression and Anxiety
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Review Article

Estrogen and Transdiagnostics: A Systematic Review

Izabel Barreto de Almeida1,2*, Antonio Egidio Nardi1,2, Ana Claudia Corrêa de Ornelas Maia1,2 and Michelle Levitan1,2

1Institute of Psychiatry, Federal University of Rio de Janeiro, Brazil

2Laboratory of Panic and Respiration, INCT Translational Medicine, Brazil

*Corresponding Author:
Izabel Barreto de Almeida
Institute of Psychiatry,Federal University of Rio de Janeiro
Laboratory of Panic and Respiration–INCT Translational Medicine
R Visconde de Pirajá, 407/702 - Rio de Janeiro– RJ – 22410-003, Brazil
Tel- 5521-25216147
Fax- 5521-25236839
E-mail: [email protected]

Received January 12, 2016; Accepted April 26, 2016; Published April 30, 2016

Citation: De Almeida IB, Nardi AE, De Ornelas Maia ACC, Levitan M (2016) Estrogen and Transdiagnostics: A Systematic Review. J Depress Anxiety 5:228. doi:10.4200/2167-1044.1000228

Copyright: © 2016 De Almeida T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: To evaluate, through systematic review, whether the role of estrogen influences the onset of disorders in anxiety and depression.

Data Sources: The search was performed in two databases, ISI Web of Science and PubMed, using the terms estrogen, anxiety and mood.

Study selection: The search produced 1060 references. Those that were repeated or not written in English were excluded. After analysis of the abstracts, 38 were selected to have their texts read, of which 18 were chosen for the execution of this review.

Data collection: The PubMed and ISI Web of Science articles were extracted in June 2015. Moreover, the study was also restricted to articles that involved adult patients and were elaborated between 2005 and 2015.

Results: There were six case-control observational studies, followed by four randomized clinical trials. The results in smaller quantities in the review were: three retrospective cohort observational studies and three cross-sectional studies, followed by one prospective cohort observational study. A letter to an editor was also included. The result that stood out in the review was the finding that women are twice as likely to suffer from disturbances of anxiety or mood, such as generalized anxiety disorder, panic disorder, post-traumatic stress disorder and bipolar disorder.

Conclusion: Some women there is a greater vulnerability to hormonal oscillations of estrogen (in pre-menstrual and postpartum periods and in the pre-menopause) leading to the aforementioned disorders


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