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ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Research Article

Ethnic Diversity in Beta-Cell Function Susceptibility to Pancreatic Triglyceride Levels: Pilot Investigation

Ildiko Lingvay1, Ruchi Mathur2, Edward W Szczepaniak2 and Lidia S Szczepaniak2*

1Southwestern Medical Center, Department of Internal Medicine, University of Texas, USA

2Cedars-Sinai Medical Center, Department of Medicine and Biomedical Sciences, USA

*Corresponding Author:
Lidia S Szczepaniak
Cedars-Sinai Medical Center
Department of Medicine and Biomedical Sciences, 8700 Beverly Blvd
Thalians E339, Los Angeles, CA 90048, USA
Tel: (310) 248-7692
Fax: (310) 248-5090
E-mail: [email protected]

Received date: January 22, 2014; Accepted date: March 22, 2014; Published date: March 26, 2014

Citation: Lingvay I, Mathur R, Szczepaniak EW, Szczepaniak LS (2014) Ethnic Diversity in Beta-Cell Function Susceptibility to Pancreatic Triglyceride Levels: Pilot Investigation. J Diabetes Metab 5:348. doi: 10.4172/2155-6156.1000348

Copyright: © 2014 Lingvay I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aims: Type 2 diabetes is a progressive disease and highly prevalent in Hispanic and Black minorities in the United States. Our research suggested that Black, compared to Hispanic and non-Hispanic White accumulate less of triglyceride within pancreatic tissue. Herein we describe ethnicity specific aspects of the relationship between pancreatic TG levels and beta cell function.

Methods: We studied 68 women: 16 Black, 26 Hispanic and 26 non-Hispanic White. We assessed insulin secretion and insulin sensitivity using frequently sampled glucose tolerance test - FSIVGTT, abdominal fat distribution using magnetic resonance imaging - MRI, and pancreatic triglyceride levels using proton magnetic resonance spectroscopy - 1H MRS.

Results: Characteristics and results were similar for non-Hispanic White and Hispanic women, hence, we considered White and Hispanic as one group. In Hispanic/White pancreatic TGs were low in lean, elevated in obese and highest in type 2 diabetes. Beta-cell function, measured as a disposition index was lower in obese compared to lean and lowest in type 2 diabetes. Furthermore, pancreatic triglyceride (pTG) and the disposition index (DI) were inversely correlated: DI 251 660 pTG = + , R2=0.4099. In non-Hispanic Black pancreatic triglyceride content was lower than in Hispanic/White, lowest in lean and marginally elevated in obese and type 2 diabetes. Beta cell function was low/normal in lean, significantly augmented in obese and reduced in type 2 diabetes. Unlike in Hispanic/White, in Blacks beta cell function expressed by DI was linearly proportional to pTG content: DI= 328*pTG + 430, R2=0.4472.

Conclusions: The results of this research suggest an ethnicity specific relationship of beta-cell function and pTG content. In Hispanics/Whites, high pancreatic TG levels potentially represent the risk factor for beta-cell failure. In obese Blacks however, hypersensitivity of beta-cell to elevated pTGs and subsequent exaggerated glucose stimulated insulin secretion may represent the ultimate risk factor for the future advance to beta-cell failure.

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