alexa Ethyl Pyruvate Inhibits Pancreatic Tumor Growth in Mice
ISSN: 2165-7092

Pancreatic Disorders & Therapy
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Research Article

Ethyl Pyruvate Inhibits Pancreatic Tumor Growth in Mice

Qian-Qian Li1, Xue-Feng Lu1, Chong-Qi Jia2, Xu-Yang Liang1, Jun-Ying Jia1, Ke-Qiang Yan3 and Bao-Quan Cheng1*
1Department of Gastroenterology, Qilu Hospital, School of Medicine, Shandong University, Jinan 250012, PR China
2Department of Epidemiology and Health Statistics, Shandong University, Jinan 250012, PR China
3Department of Urology, Qilu Hospital, School of Medicine, Shandong University, Jinan 250012, PR China
Corresponding Author : Bao-Quan Cheng
Department of Gastroenterology, Qilu Hospital
School of Medicine, Shandong University
Jinan 250012, PR China
Tel: +86 13853198938
E-mail: [email protected]
Received June 04, 2012; Accepted July 25, 2012; Published July 30, 2012
Citation: Li QQ, Lu XF, Jia CQ, Liang XY, Jia JY, et al. (2012) Ethyl Pyruvate Inhibits Pancreatic Tumor Growth in Mice. Pancreatic Dis Ther 2:104. doi:10.4172/2165-7092.1000104
Copyright: © 2012 Li QQ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Abstract Objective: We evaluate the anti-tumor effect of Ethyl Pyruvate (EP) on the human pancreatic cancer xenograft in nude mice. Methods: Human pancreatic cancer cell line SW1990 was used in vivo to investigate the effect of EP on the human pancreatic cancer in mice. The mice were treated with different doses of EP (100 mg/kg, 50 mg/kg, i. p. ) initiating 1 hour (early treatment) after tumor cells injection daily for 14 days, and EP (100 mg/kg, i. p. ) was administered beginning12 days (delayed treatment) after tumor cells injection daily for 14 days. Tumor volumes were measured. ELISA was used to measure tumor necrosis factor (TNF) -α, interleukin (IL) -1β, IL-6 and high mobility group box 1 (HMGB1). Results: EP administration inhibited pancreatic tumor growth significantly. The differences in tumor volumes were statistical significant (P=0.0001) and in tumor weights (P=0.0028) between treatment and untreated groups. Treatment with the higher (100 mg/kg) dose of EP conferred better efficacy than lower (50 mg/kg) group (P=0.024). Early treatment with EP inhibited tumor significantly than delayed treatment (P=0.001). Early administration of EP inhibits TNF-α, IL-1β, IL-6 and HMGB1 release. Conclusions: EP may have potential as a therapeutic candidate for the treatment of pancreatic cancer.

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