alexa Etiopathogenesis of Melasma
ISSN: 2376-0427

Dermatology and Dermatologic Diseases
Open Access

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Previously: Journal of Pigmentary Disorders

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Research Article

Etiopathogenesis of Melasma

Fabrizio Guarneri*
Department of Clinical and Experimental Medicine – Dermatology, University of Messina, Messina, Italy
Corresponding Author : Guarneri F
Viale Annunziata, Residence dei Fiori
villa 7 98168 Messina, Italy
Tel: +39 090 357070
Fax: +39 090 2927691
E-mail: [email protected]
Received October 20, 2014; Accepted October 22, 2014; Published October 24, 2014
Citation: Guarneri F (2014) Etiopathogenesis of Melasma. Pigmentary Disorders S1:003. doi: 10.4172/2376-0427.1000S1003
Copyright: © 2014 Guarneri F. The terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Known since ancient times, melasma is notoriously a frequent dyspigmentation disorder characterized by localized, chronic acquired cutaneous hypermelanosis. Despite high frequency, significant negative effects on quality of life and often unsatisfactory results of available treatment, not much research has been performed on the etiopathogenesis of this disease, which still remains largely obscure. An extensive review of the literature on etiology and pathogenesis of melasma is presented here, in which known causal/exacerbating factors (sun exposure, alterations of hormonal balance, use of cosmetics and photosensitizing drugs, procedures and inflammatory processes of the skin, stressful events) are linked with their effects on multiple metabolic pathways of melanocytes and other components of the socalled “melanin unit”. Available data outline an incompletely defined, but certainly complex and somehow fascinating network of interactions of structural and functional alterations, which deserves further investigation, not only to obtain new and better treatments for melasma, but also –and probably more important in view of a more detailed understanding of the entire physiology and pathophysiology of melanogenesis, with many possible applications in the vast field of dyspigmentation disorders

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