Evaluation of Antidiabetic Potential of Pinus roxburghii Bark Extract in Alloxan Induced Diabetic RatsKaushik P, Khokra SL and Kaushik D*
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana, India
- *Corresponding Author:
- Dhirender Kaushik
Institute of Pharmaceutical Sciences
Kurukshetra University, Kurukshetra-136119, Haryana, India
Email: [email protected]
Received date: September 11, 2015; Accepted date: October 06, 2015; Published date: October 10, 2015
Citation: Kaushik P, Khokra SL and Kaushik D (2015) Evaluation of Antidiabetic Potential of Pinus roxburghii Bark Extract in Alloxan Induced Diabetic Rats. J Pharmacogn Nat Prod 1:105. doi: 10.4172/2472-0992.1000105
Copyright: © 2015 Kaushik D et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In the present study we investigated the possible anti-diabetic potential of Pinus roxburghii Sarg. in alloxan induced diabetic rat. Diabetes was induced in rats by injecting them with alloxan (120 mg/kg body weight). Control rats were either healthy untreated, or diabetes induced untreated rats which only received distilled water. The acute effect of ethanol extract was evaluated by administering 100, 300, 500 mg/kg body weight p.o. to normoglycemic rats. In the chronic model, the ethanol extract was administered to normal and alloxan-induced-diabetic rats at dose of 100, 300, 500 mg/kg body weight p.o. per day for 21 days. Blood glucose levels and body weights were monitored at specific intervals and different biochemical parameters were also carried out. The statistical data indicated the significant (p<0.01) increase in the body weight and decrease in the blood glucose, glycated hemoglobin levels, total cholesterol and serum triglycerides. HDL cholesterol level was significantly (p<0.01) increased when treated with the extract. Quercetin isolated from the bark of plant showed α-amylase inhibitory activity .Hence, it can be concluded that antihyperglycemic and antihyperlipidemic activities of ethanol extract of Pinus roxburghii Sarg. Bark may be due to the presence of phytoconstituents like flavanoids.