Evaluation of Anxiolytic Activity of Ixora coccinea Linn. Ethanolic Extract in Swiss Albino MiceShan P Mohammed*, Nasiya Latheef and Sri Ganeshan P
Regional Institute of Medical Sciences and Research, Mahatma Gandhi University, Puthupally, Kottayam-686009, India
- *Corresponding Author:
- Shan P Mohammed
Regional Institute of Medical Sciences and Research
Mahatma Gandhi University, Puthupally, Kottayam-686009, India
E-mail: [email protected]
Received date: January 01, 2014; Accepted date: January 15, 2014; Published date: January 22, 2014
Citation: Mohammed SP, Latheef N, Sri Ganeshan P (2014) Evaluation of Anxiolytic Activity of Ixora coccinea Linn. Ethanolic Extract in Swiss Albino Mice. Clin Exp Pharmacol 4:146. doi:10.4172/2161-1459.1000146
Copyright: © 2014 Mohammed SP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Ixora coccinea Linn. (Family: Rubiaceae), a small to medium sized hardy shrub is cultivated for ornamental purpose and also it finds place in traditional Indian medicine. The objective of this study was to evaluate the anxiolytic activity of Ixora coccinea ethanolic extract. The methods used for this study are elevated plus maze paradigm test and Hole board test. The ethanolic extract ICEE shows a significant (P<0.01) anxiolytic effect during the elevated plus maze test and the hole board test in a dose dependent manner when compared with the standard dose of diazepam.