alexa Evaluation of Arteriosclerotic Vascular Disease with a
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Review Article

Evaluation of Arteriosclerotic Vascular Disease with a New Noble Stiffness Indicator, Cardio-Ankle Vascular Index (CAVI)

Kohji Shirai1,4*, Junji Utino4, Atsuhito Saiki2, Ichiro Tatsuno2, Kazuhiro Shimizu3 and Mao Takahashi3
1Department of Vascular Function, Sakura Hospital, School of Medicine, Toho University, Chiba, Japan
2Diabetes Endocrine and Metabolism Center, Sakura Hospital, School of Medicine, Toho University, Chiba, Japan
3Cardiovascualr center, Sakura Hospital, School of Medicine, Toho University, Chiba, Japan
4Mihama Hospital, Chiba, Japan
Corresponding Author : Kohji Shirai, MD, Ph.D
Department of Vascular Function
Sakura Hospital, School of Medicine
Toho University, 564-1 Shimoshizu, Sakurashi
Chiba 285-8741, Japan
Tel: 81-43-462-8811
Fax: 81-43-489-9770
E-mail: [email protected]
Received June 23, 2012; Accepted August 27, 2012; Published August 27, 2012
Citation: Shirai K, Utino J, Saiki A, Tatsuno I, Shimizu K, et al. (2012) Evaluation of Arteriosclerotic Vascular Disease with a New Noble Stiffness Indicator, Cardio- Ankle Vascular Index (CAVI). J Clin Exp Cardiolog S1:004. doi: 10.4172/2155-9880.S1-004
Copyright: © 2012 Shirai K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Arterial stiffness is a well-known predictor of arteriosclerotic vascular disease. One index of arterial stiffness was the pulse wave velocity (PWV). But, it is known that PWV depends on the blood pressure at measuring time. Cardio-ankle vascular index (CAVI) is derived from stiffness parameter beta, and reflects the stiffness of the artery from the origin of the aorta to the ankle as a whole. Conspicuous feature is independency from the blood pressure at measuring time. An administration of alfa-1 blocker, doxazosin decreased CAVI transiently. Prostacyclin analogue, beraprost also decreased CAVI. These results suggest that CAVI might reflect the smooth muscle cell contracture. CAVI showed high value with aging, and in patients with cerebral infarction, coronary stenosis, and chronic hemodialysis, suggesting that CAVI is reflecting systemic vascular arteriosclerosis. As for the risks of coronary artery disease, CAVI showed high value in hypertension, diabetes mellitus, dyslipidemia, smoking and metabolic syndrome. Improvement of those risk factors reduced CAVI. CAVI seems to be a useful indicator for the management of the risk factors. Arterial inflammatory diseases also showed high CAVI value. Furthermore, various associations between CAVI and cardiac functions such as left ventricular diastolic function were reported. Above results suggested that CAVI reflect the degrees of arteriosclerosis and of ages, and also reflect the contracture of arterial smooth muscle cells. CAVI might be useful to investigate a new insight of vascular function.

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