Evaluation of Biliary Secretory Immunoglobulin-A in Recipients of Living-Donor Liver Transplantation
|Kentaro Yamagiwa1,*, Yusuke Iizawa1, Motoyuki Kobayashi1, Toru Shinkai1, Takashi Hamada2, Shugo Mizuno2, Masanobu Usui2, Hiroyuki Sakurai2, Masami Tabata2, Shuji Isaji2, Shintaro Yagi3, Taku Iida3, Tomohide Hori3, Koji Fujii4 and Hajime Yokoi5|
|1Department of Surgery, Mie Prefectural Shima Hospital, Japan|
|2Department of Hepatobiliary-Pancreatic Transplant Surgery, Mie University Graduate School of Medicine, Japan|
|3Department of Hepatobiliary-Pancreatic Surgery and Transplantation, Graduate School of Medicine, Kyoto University, Japan|
|4Department of Surgery, Yamada Red Cross Hospital, Japan|
|5Department of Surgery, Mie Chuo Medical Center, Japan|
|Corresponding Author :||Yamagiwa, MD
Director, Department of Surgery
Mie Prefectural Shima Hospital Ugata 1257
Agocho, Shima City, Mie
E-mail: [email protected]
|Received March 14, 2012; Accepted May 17, 2012; Published May 22, 2012|
|Citation: Yamagiwa K, Iizawa Y, Kobayashi M, Shinkai T, Hamada T, et al. (2012) Evaluation of Biliary Secretory Immunoglobulin-A in Recipients of Living-Donor Liver Transplantation. J Liver 1:106. doi:10.4172/2167-0889.1000106|
|Copyright: © 2012 Yamagiwa K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Introduction: The importance of measuring Secretory Immunoglobulin A (sIg-A) levels in clinical samples from the recipients of liver transplantation is still unclear. An observational study was conducted to investigate the importance of biliary sIg-A in the early period after Living-Donor Liver Transplantation (LDLT).
Methods: The biliary sIg-A level (μg/ml) of 18 patients who underwent LDLT, and a control group of 5 patients who underwent Choledochotomy (CDT) in the Department of Hepatobiliary-Pancreatic Transplant Surgery of Mie University Hospital between 2003 and 2005 was measured on Postoperative Day 7 (POD 7). The biliary sIg-A levels were compared with 11 clinical variables including portal venous Interleukin (IL)-6 levels and Portal Venous Pressure (PVP), on POD 7 in the LDLT group.
Results: The biliary sIg-A levels in the LDLT group (102.8 ± 74.8) were significantly higher (p=0.014) than in the CDT group (11.7 ± 5.6). Postoperative complications developed in 6 patients (33%) in the LDLT group, but there were no significant differences between the biliary sIg-A levels according to whether the patients had developed postoperative complications. There were significant positive correlations between the biliary sIg-A levels and portal venous IL-6 (p<0.006) levels, PVP values (p<0.015), and serum T-Bil (p<0.023) values in the LDLT group.
Conclusions: The measurement of biliary sIg-A in the early period after LDLT is thought to be useful for analyzing postoperative complications with high PVP and hyperbilirubinemia.