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Evaluation of Biliary Secretory Immunoglobulin-A in Recipients of Living-Donor Liver Transplantation | OMICS International | Abstract
ISSN: 2167-0889

Journal of Liver
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Research Article

Evaluation of Biliary Secretory Immunoglobulin-A in Recipients of Living-Donor Liver Transplantation

Kentaro Yamagiwa1,*, Yusuke Iizawa1, Motoyuki Kobayashi1, Toru Shinkai1, Takashi Hamada2, Shugo Mizuno2, Masanobu Usui2, Hiroyuki Sakurai2, Masami Tabata2, Shuji Isaji2, Shintaro Yagi3, Taku Iida3, Tomohide Hori3, Koji Fujii4 and Hajime Yokoi5
1Department of Surgery, Mie Prefectural Shima Hospital, Japan
2Department of Hepatobiliary-Pancreatic Transplant Surgery, Mie University Graduate School of Medicine, Japan
3Department of Hepatobiliary-Pancreatic Surgery and Transplantation, Graduate School of Medicine, Kyoto University, Japan
4Department of Surgery, Yamada Red Cross Hospital, Japan
5Department of Surgery, Mie Chuo Medical Center, Japan
Corresponding Author : Yamagiwa, MD
Director, Department of Surgery
Mie Prefectural Shima Hospital Ugata 1257
Agocho, Shima City, Mie
Japan 517-0595
Tel: +81-599-43-0501
Fax: +81-599-43-6109
E-mail: [email protected]
Received March 14, 2012; Accepted May 17, 2012; Published May 22, 2012
Citation: Yamagiwa K, Iizawa Y, Kobayashi M, Shinkai T, Hamada T, et al. (2012) Evaluation of Biliary Secretory Immunoglobulin-A in Recipients of Living-Donor Liver Transplantation. J Liver 1:106. doi:10.4172/2167-0889.1000106
Copyright: © 2012 Yamagiwa K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Introduction: The importance of measuring Secretory Immunoglobulin A (sIg-A) levels in clinical samples from the recipients of liver transplantation is still unclear. An observational study was conducted to investigate the importance of biliary sIg-A in the early period after Living-Donor Liver Transplantation (LDLT).

Methods: The biliary sIg-A level (μg/ml) of 18 patients who underwent LDLT, and a control group of 5 patients who underwent Choledochotomy (CDT) in the Department of Hepatobiliary-Pancreatic Transplant Surgery of Mie University Hospital between 2003 and 2005 was measured on Postoperative Day 7 (POD 7). The biliary sIg-A levels were compared with 11 clinical variables including portal venous Interleukin (IL)-6 levels and Portal Venous Pressure (PVP), on POD 7 in the LDLT group.

Results: The biliary sIg-A levels in the LDLT group (102.8 ± 74.8) were significantly higher (p=0.014) than in the CDT group (11.7 ± 5.6). Postoperative complications developed in 6 patients (33%) in the LDLT group, but there were no significant differences between the biliary sIg-A levels according to whether the patients had developed postoperative complications. There were significant positive correlations between the biliary sIg-A levels and portal venous IL-6 (p<0.006) levels, PVP values (p<0.015), and serum T-Bil (p<0.023) values in the LDLT group.

Conclusions: The measurement of biliary sIg-A in the early period after LDLT is thought to be useful for analyzing postoperative complications with high PVP and hyperbilirubinemia.