Evaluation of Carbohydrate and Lipid Metabolism and Risk of Obesity in Children after Brain Tumors TreatmentMaja Okońska1*, Elżbieta Adamkiewicz-Drożyńska2, Maria Korpal-Szczyrska1, Dorota Birkholz-Walerzak1 and Małgorzata Myśliwiec1
- *Corresponding Author:
- Maja Okonska
Department of Pediatric Diabetology
Clinic of Pediatrics, Diabetology and Endocrinology
Medical University of Gdansk, ul. Debinki 7, 80-952 Gdansk, Poland
E-mail: [email protected]
Received date: May 12, 2014; Accepted date: June 25, 2014; Published date: July 02, 2014
Citation: Okonska M, Adamkiewicz-Drozynska E, Korpal-Szczyrska M, Birkholz-Walerzak D, Mysliwiec M (2014) Evaluation of Carbohydrate and Lipid Metabolism and Risk of Obesity in Children after Brain Tumors Treatment. J Steroids Hormon Sci 5:137. doi:10.4172/2157-7536.1000137
Copyright: © 2014 Okonska M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The aim of the study was to assess the carbohydrate and lipid metabolism disturbances as well as weight in children after brain tumors treatment.
The study included 33 boys (53.2%) and 29 girls (46.8%) aged 11.6 ± 3.9. 22 patients underwent treatment for tumors of hypothalamic-pituitary(h-p) area: IA–surgery(19/22); IB–surgery and radiotherapy(3/22). 40 patients were treated for tumors outside the h-p area: IIA– with surgery, chemo-and radiotherapy(22/40); IIB–only with surgery(15/40); IIC–patients treated for optic nerve glioma with chemotherapy(3/40).
BMI was assessed before and after the treatment. OGTT, HbA1c, lipid profile and WHtR after treatment were assessed. Indices of insulin resistance: HOMA-IR, Quickie, Matsuda and de Fronzo were calculated.
63% overweight/obese patients of IA-group and 27% of IIA-group were observed. Hyperinsulinemia was noted in 44% of IA-group, 20% of IIA-group, and insulin resistance in 38% of IA and 15% of IIA. DM2 was diagnosed in 1 patient of IA-group, IFG in 1 patient of IIB, IGT in 1 patient of IA and 1 patient of IIC. Dyslipidemia was noted in 47% of IA-group, elevated level of LDL-cholesterol in 30% of IIA-group.
The excessive weight gain, hyperinsulinemia and dyslipidemia were observed primarily in children treated for hypothalamic-pituitary tumors.