alexa Evaluation of Carbonylated Proteins in Hepatitis C Viru
ISSN: 2329-6798

Modern Chemistry & Applications
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Evaluation of Carbonylated Proteins in Hepatitis C Virus Patients

Mahmoud Mohamed Alou-El-Makarem1*, Moussa Madany Moustafa1, Mohamed Abdel-Aziz Fahmy1, Aamer Mohamed Abdel-Hamed1, Khaled Nagy El-fayomy3 and Medhat Mohamed Abdel-Salam Darwish2
1Department of Medical Biochemistry, Al Azhar University, Cairo, Egypt
2Faculty of Medicine, Al Azhar University, Damietta, Cairo, Egypt
3Department of Internal Medicine, Al Azhar University, Damietta, Cairo, Egypt
Corresponding Author : Mahmoud Mohamed Alou-El-Makarem
Department of Medical Biochemistry
Al Azhar University, Cairo, Egypt
Tel: 02-115-400-0554
E-mail: [email protected]
Received March 17, 2014; Accepted July 11, 2014; Published July 16, 2014
Citation: Alou-El-Makarem MM, Moustafa MM, Fahmy MA, Abdel-Hamed AM, Elfayomy KN, et al. (2014) Evaluation of Carbonylated Proteins in Hepatitis C Virus Patients. Mod Chem appl 2:130. doi:10.4172/2329-6798.1000130
 
Copyright: © 2014 Alou-El-Makarem MM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 
Related article at
DownloadPubmed DownloadScholar Google
 

Abstract

Carbonylated proteins are irreversible posttranslational oxidative modifications, which may interfere with the normal homeostasis of cell growth inducing liver cirrhosis and risk of malignancy. Objective: To determine plasma levels of carbonylated proteins and total antioxidant capacity and evaluate their role in HCV hepatitis patients and HCV induced liver cirrhosis before and after antiviral therapy; interferon and ribavirin. Methods: This study included twenty chronic hepatitis C patients with cirrhotic changes, twenty chronic hepatitis C patients without cirrhotic changes and before taking interferon therapy and Fifteen chronic hepatitis C patients without cirrhotic changes and after taking antiviral therapy; interferon (PEG-IFN α2a 180-μg/week and Ribavirin 800 mg capsule one time daily for 24 weeks). Twenty male healthy individuals were included as the control group (age, and body mass index matched). All patients were taking liver support supplements containing vitamins; C, E, folic acid and carotenoids. Results: There was a highly significant increase (p value 0.00001) in plasma carbonylated protein level in cirrhotic patients (44.9 ± 5.63 nM/dL) as compared to the control group (22.3 ± 3.35 mM/L). TAC in serum in cirrhotic patients was significantly decreased to 0.765 ± 0.249 mM/L as compared to all other groups. These patients were taking antioxidants vitamins (vitamin C, carotenoids and vitamin E), and other supplements known to have antioxidant effects (silimaryn, trace elements), which did not increase their TAC. Conclusions: Carbonylated proteins may play a role in HCV induced liver cirrhosis. The currently used antioxidants did not increase the antioxidant capacity of plasma. New antioxidants as well as inducers of antioxidant enzymes may be helpful in increasing TAC and prevention of formation of carbonylated proteins and liver cirrhosis.

Keywords

Related Subjects

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords