alexa Evaluation of Clinical Characteristics and Biomarkers a
ISSN: 2167-0870

Journal of Clinical Trials
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Research Article

Evaluation of Clinical Characteristics and Biomarkers after Endovenous Foam Sclerotherapy for Venous Disorders

Suman Rathbun1*, Ryan Zander2, Richard A Marlar3, Pravina Kota2, Ying Zhang2, Thomas Whitsett1 and Julie A Stoner2
1Department of Medicine, Cardiovascular section, University of Oklahoma Health Sciences Center, USA
2Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, USA
3Department of Pathology, University of Oklahoma Health Sciences Center, USA
*Corresponding Author : Suman W Rathbun
Vascular Medicine, University of Oklahoma Health Sciences Center
920 Stanton L Young Blvd. WP 3120, OK 73014, USA
Tel: +1-405-271-4742
Fax: +1-405-271-2914
E-mail: [email protected]
Received date: March 30, 2016; Accepted date: April 20, 2016; Published date: April 27, 2016
Citation: Rathbun S, Zander R, Marlar RA, Kota P, Zhang Y, et al. (2016) Evaluation of Clinical Characteristics and Biomarkers after Endovenous Foam Sclerotherapy for Venous Disorders. J Clin Trials 6:263. doi:10.4172/2167-0870.1000263
Copyright: © 2016 Rathbun S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Objective: Endovenous foam sclerotherapy (EFS) is widely performed in the U.S, but there is a paucity of studies evaluating clinical predictors of outcomes, including biomarkers, in patients with venous disorders.
Methods: Patients undergoing EFS monotherapy for venous disorders were enrolled. Evaluation at baseline, 1 week, 12 weeks, and 26 weeks included clinical characteristics and biomarker analysis.
Results: 100 patients with venous disease were treated. At one week follow-up, 44% underwent a second injection. At 3 months, 100% of patients had obliteration of at least 80% of their affected veins, and 96% reported improved venous stasis symptoms. Adverse events were minor and deep vein thrombosis was found 4 patients at 3 months. D-dimer levels were significantly higher at week one, but returned to baseline by week 12; fibrin monomer decreased and PPL increased at one week and 3 months relative to baseline.
Conclusion: EFS monotherapy is effective in treating signs and symptoms of venous disease with few adverse effects. D-dimer levels are significantly associated with obliteration of venous segments suggesting an association between vein obliteration and activation of coagulation.

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