alexa Evaluation of Direct Esterification of Fatty Acid Derivative of Kojic Acid in Co-solvent System: A Statistical Approach
ISSN: 2157-7048

Journal of Chemical Engineering & Process Technology
Open Access

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Research Article

Evaluation of Direct Esterification of Fatty Acid Derivative of Kojic Acid in Co-solvent System: A Statistical Approach

Fatin Amirah Ahmad Norddin1 Sharifah Nurfadhlin Afifah Syed Azhar1,2 and Siti Efliza Ashari1,2*

1Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

2Process Engineering Laboratory, Enzyme and Microbial Technology Research Center (EMtech), Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia

*Corresponding Author:
Siti Efliza Ashari
Department of Chemistry, Faculty of Science
Universiti Putra, 43400 UPM Serdang, Selangor
Tel: +389467265
E-mail: [email protected]

Received date: March 27, 2017; Accepted date: April 11, 2017; Published date: April 16, 2017

Citation: Norddin FAA, Azhar SNAS, Ashari SE (2017) Evaluation of Direct Esterification of Fatty Acid Derivative of Kojic Acid in Co-solvent System: A Statistical Approach. J Chem Eng Process Technol 8: 331. doi: 10.4172/2157- 7048.1000331

Copyright: © 2017 Norddin FAA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The present work deals with direct esterification method to synthesize Kojic acid using immobilized lipase as a biocatalyst in acetonitrile with the addition of dimethylsulfoxide (DMSO) as a solubilizing agent Co-solvent respectively. To increase the esterification yield of KMO, modifications of the process were evaluated, including the use of a cosolvent and the use of Novozyme 435 (Candida antarctica) as a catalyst. The KMO synthesis has been developed and optimized by using Response Surface Methodology (RSM) with Central Composite Rotatable Design (CCRD). The optimized condition of enzyme was 3.35 wt% and 1:3.64 molar ratio of kojic acid and oleic acid at 82.39°C for 255.24 min of reaction. With these condition, the maximum percentage yield was 42.73% with R2 value of 0.866914 and indicated that 86.69% of the variability in the response could be explained by the model. The model was significant and fitted well with the experimental data and the lack of fit was not significant. The efficacy for cosmetic application was successfully tested and showed as non-irritating with a Human Irritancy Equivalent score between 0.55-0.83 which safe to be applied in cosmetic ingredient.


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