alexa Evaluation of Diuretic Activity of Hydro-Ethanolic Extract of Moringa Stenopetala Leaves in Swiss Albino Mice
ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
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Research Article

Evaluation of Diuretic Activity of Hydro-Ethanolic Extract of Moringa Stenopetala Leaves in Swiss Albino Mice

Bekesho Geleta1*, Mebrahtu Eyasu2, Netsanet Fekadu1, Asfaw Debella1 and Feyissa Challa3

1Directorate of Traditional and Modern Medicine Research, Ethiopian Public Health Institute, Addis Ababa, Ethiopia

2St. Paul’s Hospital Millennium Medical College, Department of Pharmacology, Addis Ababa, Ethiopia

3Directorate of TB and HIV Research, Ethiopian Public Health Institute, Addis Ababa, Ethiopia

*Corresponding Author:
Bekesho Geleta
Directorate of Traditional and Modern Medicine Research
Ethiopian Public Health Institute
P.O. Box 1242, Addis Ababa, Ethiopia
Tel: +251911091969
E-mail: [email protected]

Received date: August 18 2015 Accepted date: September 21 2015 Published date: September 25 2015

Citation: Geleta B, Eyasu M, Fekadu N, Debella A Challa F (2015) Evaluation of Diuretic Activity of Hydro-Ethanolic Extract of Moringa Stenopetala Leaves in Swiss Albino Mice. Clin Exp Pharmacol 5:190. doi: 10.4172/2161-1459.1000190

Copyright: © 2015 Geleta B. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Abstract Context: Moringa stenopetala (Baker f) Cufodontis is an evergreen tree of approximately 5 to 10 m height and widely distributed in the Southern parts of Ethiopia with numerous nutritional and medicinal purposes. Objective: The aim of the study was to evaluate the effect of hydro-ethanolic extract of M. stenopetala leaves using in-vivo mice model of diuresis. Methods: Furosemide (10 mg/kg), normal saline (1 ml/100 g), and extract doses (150, 250, 350, 500 and 1000 mg/kg) of body weight were used as standard, control and test substance respectively. All substances were administered orally. The urine output and electrolyte concentration of Na+, K+ and Cl- were determined. Results: At all doses the experimental group had a significant urine output at 0.5 hour and 1 hour (P < 0.001) compared to standard and control. After 2.5 hours, at 500 mg/kg the extract showed an increased urine output compared to the control as well as the extract doses of 150, 250, 350 and 1000 mg/kg (P < 0.05). The excretion of Na+ and Cl- was significantly increased at 250 and 350 mg/kg test doses (P < 0.001) compared to control. At 500 and 1000 mg/kg, there is a comparable Na+ and Cl- excretion and a significant K+ excretion ((at 500 (P < 0.01) and 1000 mg/kg (P < 0.01)) compared to standard and control respectively. Conclusion: The outcome of the study demonstrated the diuretic activity of the hydro-ethanolic extracts of M. stenopetala leaves which is in agreement to the folkloric use of the plant for the management of hypertension and heart failure.

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