Evaluation of Ethanolic Extract of Desmodium Gyrans DC Leaves on Wound Healing Activity in RatsGopalakrishnan S* and Rajameena R
Senior Professor and Head Department of Pharmaceutical Chemistry, Manonmaniam Sundaranar University, Tirunelveli, India
- *Corresponding Author:
- Gopalakrishnan S
Senior Professor and Head Department of Pharmaceutical Chemistry
Manonmaniam Sundaranar University
E-mail: [email protected]
Received date: July 26, 2012; Accepted date: September 20, 2012; Published date: September 25, 2012
Citation: Gopalakrishnan S, Rajameena R (2012) Evaluation of Ethanolic Extract of Desmodium gyrans DC Leaves on Wound Healing Activity in Rats. Pharmaceut Anal Acta 3:169. doi: 10.4172/2153-2435.1000169
Copyright: © 2012 Gopalakrishnan S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Desmodium gyrans DC is a well-known herb for its antidote, cardiac-tonic and wound healing activities. The present study was aimed for wound healing potential of the ethanol extract of Desmodium gyrans leaves in the form of simple ointment using two types of wound models in rats, viz. excision wound and dead space wound. The results were comparable to standard drug ciphadin ointment, in terms of wound contraction, tensile strength, histopathological and hydroxy proline content. Histopathological study showed significant increase in fibroblast cells, collagen fibres and blood vessels formation. All parameters were observed significant (p<0.01) in comparison to control group.