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ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
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Research Article

Evaluation of Genotoxic and Lipid Peroxidation Effect of Cadmium in Developing Chick Embryos

Meena Bai M, Divya K, Haseena Bhanu SK, Sailaja G, Sandhya D and Thyagaraju K*
Department of Biochemistry, Sri Venkateswara University, Tirupati, Andhra Pradesh, India
Corresponding Author : Professor Thyagaraju K
Department of Biochemistry
Sri Venkateswara University
Tirupati, 517502, Andhra Pradesh, India
Tel: 91- 9849063289
E-mail: [email protected]
Received April 09, 2014; Accepted July 28, 2014; Published July 31, 2014
Citation: Meena Bai M, Divya K, Haseena Bhanu SK, Sailaja G, Sandhya D, et al. (2014) Evaluation of Genotoxic and Lipid Peroxidation Effect of Cadmium in Developing Chick Embryos. J Environ Anal Toxicol 4:238. doi: 10.4172/2161-0525.1000238
Copyright: © 2014 Meena Bai M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Our study was aimed to evaluate the effects of cadmium on chick embryo liver tissue. 10th, 11th and 12th day old Bobcock strain chick embryos were exposed to cadmium individually, by in ovo treatment. These concentrations 40, 50, 60 μg of Cadmium at different time intervals i.e., 24, 48, 72 hr, were administered to developing chick embryo. On the 13th study day, blood and the liver tissues collected were tested for genotoxic and lipid peroxidation assays. In this study, the presence of micronucleated erythrocytes and also various abnormal cells in the blood smear indicated the role of cadmium-induced genotoxicity. Current findings showed that frequency of micronucleated erythrocytes increased with increased doses of cadmium and time interval. MDA levels were high in cadmium exposed group compared to control group. These findings suggest the genotoxic and an oxidative stress mechanism in cadmium-induced liver tissue enhances damage.

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