alexa Evaluation of Hepatoprotective Activity with different Fractions of Gardenia gummifera Linn. on Paracetamol Induced Liver Damage in Rats | OMICS International | Abstract
ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
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Research Article

Evaluation of Hepatoprotective Activity with different Fractions of Gardenia gummifera Linn. on Paracetamol Induced Liver Damage in Rats

Pradeep Kumar Sabbani1*, Ravi Chander Thatipelli1, Gurunath Surampalli1 and Prathibha Duvvala2

1Department of Pharmacology, Vaagdevi Institute of Pharmaceutical Sciences, Warangal, Andhra Pradesh, India

2Department of Medicinal Chemistry, Vaagdevi College of Pharmacy, Warangal, Andhra Pradesh, India

*Corresponding Author:
Pradeep Kumar Sabbani
Department of Pharmacology
Vaagdevi Institute of Pharmaceutical Sciences
Bollikunta, Warangal, Andhra Pradesh, India
Tel: 9866061611
E-mail: [email protected], [email protected]

Received Date: July 23, 2015 Accepted Date: February 06, 2016 Published Date: February 15, 2016

Citation: Sabbani PK, Thatipelli RC, Surampalli G, Duvvala P (2016) Evaluation of Hepatoprotective Activity with different Fractions of Gardenia gummifera Linn. on Paracetamol Induced Liver Damage in Rats. J Drug Metab Toxicol 7:199. doi: 10.4172/2157-7609.1000199

Copyright: © 2016 Sabbani PK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The hepatoprotective and antioxidant activity of methanolic extract of whole plant of Gardenia Gummifera (GGME) was evaluated against paracetamol induced liver damage in rats. And the GGME fractionated based on polarity of solvents with toluene, ethanol, 2-butanone, n-butanol and petroleum ether. The substantially elevated serum enzymatic levels of Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), Alkaline Phosphate (ALP) and total bilirubin were restored towards normalization significantly by the GGME in a dose dependent manner in paracetamol induced liver damage. The biochemical observations were supplemented with histopathological examination liver sections high protection against paracetamol induced hepatoxicity. Further investigation continued with GGME fractions, 2-Butanone Fraction (BTF) and nbutanol Fraction (BAF) substantially elevated serum enzymatic levels of AST, ALT, ALP and Total Bilirubin (TB) were restored towards normalization significantly The significant values showed with n-butanol fraction on pentobarbitone induced sleeping time in mice and the liver weight of paracetamol induced liver damaged in rats. Meanwhile, in vitro antioxidant activities such as DPPH scavenging assay was also screened which were also found significantly positive in a dose dependent manner. The results of this study strongly indicate that GGME and n-butanol fraction results potent hepatoprotective activity against paracetamol induced liver damage in experimental animals.

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