alexa Evaluation of HFE Gene (<em>C282Y</em>) Mutation and Its Association Relation with Coronary Artery Diseases in Indian Population | OMICS International | Abstract
ISSN: 2168-9547

Molecular Biology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Evaluation of HFE Gene (C282Y) Mutation and Its Association Relation with Coronary Artery Diseases in Indian Population

Naseer Ue Din Shah*, Abrar Ahmed, Falak Mushatq, Mohd Maqbool Reshi, Jasbir Kour, Hilal Ganaie and Marum Meraj

 

Cytogenetic and Molecular Biology Research Laboratory, Centre of Research for Development, University of Kashmir, Srinagar, Jammu and Kashmir, India

*Corresponding Author:
Naseer Ue Din Shah
Cytogenetic and Molecular Biology Research Laboratory
Centre of Research for Development
University of Kashmir, Srinagar-190006
Jammu and Kashmir, India
Tel: 0194 227 2096
E-mail: [email protected]

Received date: March 25, 2017; Accepted date: April 04, 2017; Published date: April 11, 2017

Citation: Shah NUD, Ahmed A, Mushatq F, Reshi MM, Kour J, et al. (2017) Evaluation of HFE Gene (C282Y) Mutation and Its Association Relation with Coronary Artery Diseases in Indian Population. Mol Biol 6:189. doi:10.4172/2168-9547.1000189

Copyright: © 2017 Din Shah NU, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: The gene associated with the CAD disease was found out to be the HFE (High Iron Fe) gene and the disease is described with the two, missense mutations of the gene– C282Y and H63D. The focus of this study was to assess the C282Y mutation in CAD patients that results from transition of guanine to adenine (G-A) at the nucleotide position 845, which in turn changes cysteine to tyrosine at the 282nd position.

Material and methods: C282Y mutation was analyzed by allele specific PCR (AS-PCR) in 100 samples which includes 96 males and 4 females. Data was collected from each patient. The blood from each patient was collected and analyzed for their cholesterol level, diabetes, RBS (Random blood sugar), LDL (low-density lipoprotein), HDL (high-density lipoproteins), TGL (Triglycerides), smoking, etc.

Results: Out of 100 patients, 12 were found to be C282 and 88 were found to be C282Y. The frequency of C282Y in CAD patients with respect to age was found to be 84 in males. Out of 88 C282Y patients 49 was found to have ≤ 140 mg RBS level and 39 patients was found to have >140 mg RBS level. The frequency of C282Y with respect to cholesterol level was found to be ≤ 200 mg in 82 patients and >200 mg in 6 patients. The frequency of C282Y with respect to HDL was found to be ≤ 40 mg in 79 patients and >40 mg in 9 patients. The frequency of C282Y with respect to LDL was found to be ≤ 100 mg in 70 patients and >100 mg in 18 patients. The frequency of C282Y with respect to TGL was found to be ≤ 150 mg in 45 patients and >150 mg in 43 patients. Out of C282Y patients 4 patients had CHD, 13 were hypertensive, 21 were diabetic, 55 were smokers and 40 were alcoholic.

Conclusion: There association between the C282Y mutation in the haemochromatosis gene and prevalence of CAD was not evident. Besides this mutation is not a threat for advanced disease or depressed ejection fraction in CAD.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version