Evaluation of Madiphalrasayan having Antiulcer Activity in Wistar Albino Rats
Peptic ulcer is one of the major diseases affecting the human population. It develops due to the imbalance between aggressive factors like acid, pepsin, H. pylori and bile salts and defensive factors like mucous, bicarbonate, blood flow, epithelial cell restoration and prostaglandins.1 The anti-ulcer activity of Madiphal rasayana [MR] was evaluated by using the experimental models of acute gastric lesions induced by ethanol and pylorus ligation in rats. Animals pre- treated with doses of 1.35ml/kg and 2.75ml/kg of MR were statistically analyzed and compared to the standard and control group with the parameters like volume of gastric secretion, PH, free acidity, total acidity and % of ulcer protection, absorbance of gastric mucus & hexosemine. The results suggested that the MR significantly decreased the volume of gastric acid secretion, free acidity, total acidity and % of ulcer protection, absorbance of gastric mucus & hexosemine in comparison with standard drug Omeprozole. MR shown significant reduction in lesion index, total affected area and percentage of lesion in comparison with control group in ethanol induced ulcer in experimental models. The gastric mucosal protective effect of MR is brought by inhibiting the gastric secretion, which shows it may act like a proton pump inhibitor. The anti-ulcer activity of MR which reduced gastric volume and total acidity in pylorus ligation ulcer model reveals that MR may act as a H2 receptor antagonist. Present study indicates that MR has anti-ulcerogenic potency in Etnanol induced and pylorus ligation induced ulcers in rats.